Optimized Diagnostic Assays Based on Redox Tagged Bioreceptive Interfaces
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2015-12-15
Autores
Bedatty Fernandes, Flavio C. [UNESP]
Patil, Amol V.
Bueno, Paulo R. [UNESP]
Davis, Jason J.
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Among the numerous label free electronic biomarker assay methodologies now available, impedance based electrochemical capacitance spectroscopy (ECS), based upon mapping the perturbations in interfacial charging of redox elements incorporated into a biologically receptive interface, has recently been shown to be a convenient and highly sensitive mode of transduction and one which, additionally, requires no predoping of analytical solution. We present, herein, a data acquisition and analysis methodology based on frequency resolved immittance function analysis. Ultimately, this enables both a maximization of assay sensitivity and a reduction in assay acquisition time by an order of magnitude.
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Analytical Chemistry, v. 87, n. 24, p. 12137-12144, 2015.