Paracoccidioidomycosis: Current perspectives from Brazil
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Data
2017-10-01
Autores
Mendes, Rinaldo Poncio [UNESP]
Cavalcante, Ricardo de Souza [UNESP]
Marques, Sílvio Alencar [UNESP]
Marques, Mariângela Esther Alencar [UNESP]
Venturini, James [UNESP]
Sylvestre, Tatiane Fernanda [UNESP]
Paniago, Anamaria Mello Miranda
Pereira, Ana Carla
da Silva, Julhiany de Fátima [UNESP]
Fabro, Alexandre Todorovic [UNESP]
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Resumo
Background: This review article summarizes and updates the knowledge on paracoccidioidomycosis. P lutzii and the cryptic species of P. brasiliensis and their geographical distribution in Latin America, explaining the difficulties observed in the serological diagnosis. Objectives: Emphasis has been placed on some genetic factors as predisposing condition for paracoccidioidomycosis. Veterinary aspects were focused, showing the wide distribution of infection among animals. The cell-mediated immunity was better characterized, incorporating the recent findings. Methods: Serological methods for diagnosis were also compared for their parameters of accuracy, including the analysis of relapse. Results: Clinical forms have been better classified in order to include the pictures less frequently observesiod. Conclusion: Itraconazole and the trimethoprim-sulfamethoxazole combination was compared regarding efficacy, effectiveness and safety, demonstrating that azole should be the first choice in the treatment of paracoccidioidomycosis.
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Palavras-chave
Antifungal compounds, Endemic mycosis, Paracoccidioides brasiliensis, Paracoccidioides lutzii, Paracoccidioidmycosis, Systemic mycosis
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Open Microbiology Journal, v. 11, p. 224-282.