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dc.contributor.authorAlves, Fernanda [UNESP]
dc.contributor.authorPavarina, Ana Cláudia [UNESP]
dc.contributor.authorMima, Ewerton Garcia de Oliveira [UNESP]
dc.contributor.authorMcHale, Anthony P.
dc.contributor.authorCallan, John Francis
dc.date.accessioned2018-12-11T17:36:47Z
dc.date.available2018-12-11T17:36:47Z
dc.date.issued2018-04-21
dc.identifierhttp://dx.doi.org/10.1080/08927014.2018.1439935
dc.identifier.citationBiofouling, v. 34, n. 4, p. 357-367, 2018.
dc.identifier.issn1029-2454
dc.identifier.issn0892-7014
dc.identifier.urihttp://hdl.handle.net/11449/179794
dc.description.abstractCandida albicans biofilms exhibit unique characteristics and are highly resistant to antifungal agents. Antimicrobial photodynamic therapy (aPDT) is an alternative treatment limited to treating superficial infections due to the poor light penetration. In this manuscript, the antifungal properties of sonodynamic therapy (SDT) were assessed. SDT uses ultrasound instead of light, enabling the treatment of deeper infections. Planktonic cells and biofilms of C. albicans were treated with aPDT or SDT, in addition to combined aPDT/SDT, with cell survival determined using colony forming units. The total biomass and structural integrity of the biofilms were also investigated. The results demonstrated that while individual aPDT or SDT eradicated suspensions, they had little impact on biofilms. However, combined aPDT/SDT significantly reduced the viability and total biomass of biofilms. Microscopic images revealed that biofilms treated with aPDT/SDT were thinner and comprised mainly of dead cells. These results highlight the potential of combined aPDT/SDT for the inactivation of C. albicans biofilms.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent357-367
dc.language.isoeng
dc.relation.ispartofBiofouling
dc.sourceScopus
dc.subjectanti-fungal
dc.subjectantimicrobial
dc.subjectbiofilms
dc.subjectCandida albicans
dc.subjectphotodynamic therapy
dc.subjectsonodynamic therapy
dc.titleAntimicrobial sonodynamic and photodynamic therapies against Candida albicansen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUlster University
dc.description.affiliationDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationSchool of Pharmacy and Pharmaceutical Sciences Faculty of Life & Health Sciences Ulster University
dc.description.affiliationUnespDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)
dc.identifier.doi10.1080/08927014.2018.1439935
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2014/01262-1
dc.description.sponsorshipIdFAPESP: 2016/00190-2
dc.identifier.scopus2-s2.0-85045749731
dc.identifier.file2-s2.0-85045749731.pdf
dc.identifier.lattes6259985899069498
dc.identifier.orcid0000-0002-9575-7625
unesp.author.lattes8867670539105403[2]
unesp.author.lattes6259985899069498(3)
unesp.author.orcid0000-0002-9231-1994[2]
unesp.author.orcid0000-0002-9575-7625(3)
dc.relation.ispartofsjr0,835
dc.relation.ispartofsjr0,835
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