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dc.contributor.authorBarros, Leonardo
dc.contributor.authorEichwald, Tuany
dc.contributor.authorSolano, Alexandre Francisco
dc.contributor.authorScheffer, Débora
dc.contributor.authorda Silva, Rodrigo Augusto [UNESP]
dc.contributor.authorGaspar, Joana M.
dc.contributor.authorLatini, Alexandra
dc.identifier.citationPhysiology and Behavior, v. 204, p. 309-323.
dc.description.abstractObesity and metabolic disorders are increasing worldwide and are associated with brain atrophy and dysfunction, which are risk factors for late-onset dementia and Alzheimer's disease. Epidemiological studies demonstrated that changes in lifestyle, including the frequent practice of physical exercise are able to prevent and treat not only obesity/metabolic disorders, but also to improve cognitive function and dementia. Several biochemical pathways and epigenetic mechanisms have been proposed to understand the beneficial effects of physical exercise on cognition. This manuscript revised central ongoing research on epigenetic mechanisms induced by exercise and the beneficial effects on obesity-associated cognitive decline, highlighting potential mechanistic mediators.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipPan American Health Organization
dc.relation.ispartofPhysiology and Behavior
dc.subjectCognitive impairment
dc.subjectGene expression
dc.titleEpigenetic modifications induced by exercise: Drug-free intervention to improve cognitive deficits associated with obesityen
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationLaboratório de Bioenergética e Estresse Oxidativo (LABOX) Departamento de Bioquímica Centro de Ciências Biológicas Universidade Federal de Santa Catarina (UFSC)
dc.description.affiliationDepartamento de Química e Bioquímica Laboratório de Bioensaios e Dinâmica Celular Universidade Estadual Paulista (UNESP) Instituto de Biociências, Campus Botucatu
dc.description.affiliationPrograma de Pós-Graduação em Bioquímica UFSC
dc.description.affiliationUnespDepartamento de Química e Bioquímica Laboratório de Bioensaios e Dinâmica Celular Universidade Estadual Paulista (UNESP) Instituto de Biociências, Campus Botucatu
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2016/01139-0
dc.description.sponsorshipIdCNPq: 304650/2016-1
dc.description.sponsorshipIdCNPq: 401842/2018-5
dc.description.sponsorshipIdCAPES: 88887.192493/2018-00
dc.description.sponsorshipIdPan American Health Organization: SCON2018-00402
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