Publicação: Study of mastoparan analog peptides against Candida albicans and safety in zebrafish embryos (Danio rerio)
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Aim: In this work, mastoparan analog peptides from wasp venom were tested against Candida albicans and safety assays were performed using cell culture and model zebrafish. Materials & methods: Minimal inhibitory concentration was determined and toxicity was performed using human skin keratinocyte and embryo zebrafish. Also, permeation of peptides through embryo chorion was performed. Results: The peptides demonstrated anti-C. albicans activity, with low cytotoxicity and nonteratogenicity in Danio rerio. The compounds had different permeation through chorion, suggesting that this occurs due to modifications in their amino acid sequence. Conclusion: The results showed that the studied peptides can be used as structural study models for novel potential antifungal agents.
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antimicrobial peptides, candidiasis, chorion, mass spectrometry, mastoparans, toxicity
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Inglês
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Future microbiology, v. 14, p. 1087-1097.
