Obesidade e vitamina D em cadelas com tumores mamários malignos
Data
2019-07-31
Autores
Nascimento, Lismara Castro do
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
A obesidade é o transtorno nutricional mais observado em cães. Em mulheres, esta condição corporal é fator predisponente para tumor de mama e é também responsável por diminuir os níveis séricos de vitamina D. Considerando as ações reguladoras e preventivas da vitamina D em células tumorais, objetivou-se pesquisar a influência da obesidade e os níveis séricos de vitamina D de cadelas com tumores mamários malignos. Para isso, foi realizada a triagem de cães, fêmeas, sem predileção por raça, com e sem tumor de mama, por meio de exames sanguíneos, cardiográficos e ultrassonográficos. Na ausência de alterações sistêmicas, os tutores foram entrevistados e dois grupos experimentais foram estabelecidos, sendo um grupo constituído por 12 cadelas saudáveis (grupo controle) e o grupo com tumor de mama maligno, por 11 cadelas de acordo com o perfil dos animais e com os resultados do Escore de Condição Corporal (ECC). Foram avaliados os níveis séricos de vitamina D, HDL, LDL, colesterol total e triglicérides; e a composição corporal no equipamento de absorciometria de raios-X de dupla energia. Após entrevista com o tutor, verificou-se que a maioria das cadelas com tumor não eram castradas, não praticavam atividade física e 18,3% apresentaram pseudociese. A análise estatística multivariada demonstrou que cadelas idosas com tumor de mama e alta porcentagem de gordura corporal apresentaram menores concentrações de 25(OH)D, quando comparadas ao grupo controle. Quanto à avaliação histopatológica, 63,7% dos tumores eram multicêntricos, sendo o carcinoma tubular o mais frequente. O presente trabalho contribui para o entendimento sobre a relação da composição corporal e dos níveis sanguíneos de vitamina D de cadelas com tumor de mama, bem como na conduta dos clínicos veterinários diante da cadela obesa e com tumor de mama.
Obesity is the most commonly observed nutritional disorder in dogs. In women, this body condition is a predisposing factor for breast tumor and is also responsible for lowering serum vitamin D levels. Considering the regulatory and preventive actions of vitamin D in tumor cells, the objective was to investigate the influence of obesity and the levels D serum levels of female dogs with malignant breast tumors. For this, dogs were screened, female, without race preference, with and without breast tumor, through blood, cardiogram and ultrasound exams. In the absence of systemic alterations, tutors were interviewed and two experimental groups were established: one group consisting of 12 healthy female dogs (control group) and the group with malignant breast tumor, 11 female dogs according to the animal profile and the results of the Body Condition Score (ECC). Serum levels of vitamin D, HDL, LDL, total cholesterol and triglycerides were evaluated; and body composition on dual energy X-ray absorptiometry equipment. After interview with the tutor, it was found that most of the female dogs with tumor were not castrated, did not practice physical activity and 18.3% had pseudocyesis. Multivariate statistical analysis showed that older female dogs with breast tumor and high body fat percentage presented lower concentrations of 25 (OH) D when compared to the control group. Regarding the histopathological evaluation, 63.7% of the tumors were multicenter, with tubular carcinoma being the most frequent. This paper contributes to the understanding of the relationship between body composition and blood levels of vitamin D in female dogs with breast tumor, as well as in the conduct of veterinary clinicians in relation to the obese dog and breast tumor.
Obesity is the most commonly observed nutritional disorder in dogs. In women, this body condition is a predisposing factor for breast tumor and is also responsible for lowering serum vitamin D levels. Considering the regulatory and preventive actions of vitamin D in tumor cells, the objective was to investigate the influence of obesity and the levels D serum levels of female dogs with malignant breast tumors. For this, dogs were screened, female, without race preference, with and without breast tumor, through blood, cardiogram and ultrasound exams. In the absence of systemic alterations, tutors were interviewed and two experimental groups were established: one group consisting of 12 healthy female dogs (control group) and the group with malignant breast tumor, 11 female dogs according to the animal profile and the results of the Body Condition Score (ECC). Serum levels of vitamin D, HDL, LDL, total cholesterol and triglycerides were evaluated; and body composition on dual energy X-ray absorptiometry equipment. After interview with the tutor, it was found that most of the female dogs with tumor were not castrated, did not practice physical activity and 18.3% had pseudocyesis. Multivariate statistical analysis showed that older female dogs with breast tumor and high body fat percentage presented lower concentrations of 25 (OH) D when compared to the control group. Regarding the histopathological evaluation, 63.7% of the tumors were multicenter, with tubular carcinoma being the most frequent. This paper contributes to the understanding of the relationship between body composition and blood levels of vitamin D in female dogs with breast tumor, as well as in the conduct of veterinary clinicians in relation to the obese dog and breast tumor.
Descrição
Palavras-chave
Cão, Mama câncer, Deficiência de vitamina D, Obesity, Domestic animals, Neoplasms