Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
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Data
2011-02-01
Autores
Gomes, Paulo C. [UNESP]
de Souza, Bibiana M. [UNESP]
Dias, Nathalia B. [UNESP]
Cesar-Tognoli, Lilian M. M. [UNESP]
Silva-Filho, Luiz C. [UNESP]
Tormena, Claudio F.
Rittner, Roberto
Richardson, Michael
Cordeiro, Marta N.
Palma, Mario Sergio [UNESP]
Título da Revista
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Editor
Pergamon-Elsevier B.V. Ltd
Resumo
Nigriventrine was isolated from the armed spider Phoneutria nigriventer, in which it constitutes about 0.4% of the total venom content. Its structure was determined to be [1,1`-(1-hydroxyhydrazine-1,2-diyl)bis(oxy)bis(4-hydroxy-2,6-dioxopiperidine-4 carboxylic acid)] by NMR, HR-ES/IMS and MS/MS methods. The intracerebroventricular application of nigriventrine in rat brain, followed by the detection of c-Fos protein expression, indicated that the compound was neuroactive in the motor cortex, sensory cortex, piriform cortex, median preoptic nucleus, dorsal endopiriform nucleus, lateral septal nucleus and hippocampus of rat brain. Nigriventrine causes convulsions in rats, even when peripherally applied. (c) 2010 Elsevier Ltd. All rights reserved.
Descrição
Palavras-chave
Spider venom, Spectroscopy, Low molecular mass, Neurotoxin, Glutamate receptor, Natural product
Como citar
Toxicon. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 2, p. 266-274, 2011.