CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIA
Nenhuma Miniatura disponível
Data
1993-01-01
Autores
Deoliveira, S. L.
Dasilva, M. F.
Soares, AMVD
Silva, C. L.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Springer
Resumo
The antibody response against the antigen sheep red blood cells (SRBC) was investigated in mice pre-treated with formalin-killed Paracoccidioides brasiliensis or with cell wall fractions of the fungus. Pre-treatment with P. brasiliensis, as well as with the F1 fraction and beta-glucan significantly increased the anti-SRBC antibody response in the experimental groups as compared to the control group that received only SRBC. This immunomodulatory effect varied with the different doses employed and with pre-treatment time. We conclude that the cell wall fractions of P. brasiliensis might play an important role in the hypergammaglobulinemia associated with Paracoccidioidomycosis.
Descrição
Palavras-chave
BETA-GLUCAN, CELL WALL, HYPERGAMMAGLOBULINEMIA, PARACOCCIDIOIDOMYCOSIS, PARACOCCIDIOIDES-BRASILIENSIS
Como citar
Mycopathologia. Dordrecht: Springer, v. 121, n. 1, p. 1-5, 1993.