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dc.contributor.authordos Santos, Elisangela
dc.contributor.authorLeitão, Maicon Matos
dc.contributor.authorAguero Ito, Caren Naomi
dc.contributor.authorSilva-Filho, Saulo Euclides
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.authorSilva-Comar, Francielli Maria de Souza
dc.contributor.authorNakamura Cuman, Roberto Kenji
dc.contributor.authorOliveira, Rodrigo Juliano
dc.contributor.authorNazari Formagio, Anelise Samara
dc.contributor.authorLeite Kassuya, Cândida Aparecida
dc.identifier.citationJournal of Ethnopharmacology, v. 269.
dc.description.abstractEthnopharmacological relevance: Leaves from Ocimum kilimandscharicum Gürke (Lamiaceae) are popularly used against articular pain. Aim of study: The aim of this study was to test the anti-inflammatory and anti-hyperalgesic (analgesic) properties of the essential oil and camphor isolated from O. Kilimandscharicum leaves (EOOK) in 4 models including zymosan induced-articular inflammation model in mice. Material and methods: For in vivo models, EOOK was tested in carrageenan-induced paw edema model with oral doses of 30, 100, and 300 mg/kg (oral administration = p.o.) and in zymosan-induced articular inflammation (including knee edema, leukocyte infiltration, mechanical hyperalgesia and nitric oxide), EOOK (100 mg/kg, p. o.) and camphor (30 mg/kg, p. o.) were tested. EOOK (100 mg/kg, p. o.) was tested in the rolling and also in the adhesion of leukocytes to the mesenteric microcirculation in situ model of carrageenan induced inflammation and EOOK (1, 3, 10, 30, and 60 μg/mL) was tested in vitro against neutrophils chemotaxis induced by N-formyl methionyl leucyl phenylalanine (fMLP). Results: The treatment with EOOK significantly inhibited the carrageenan-induced edema, mechanical and cold hyperalgesia. Both, EOOK and camphor inhibited all articular parameters induced by zymosan. In situ intravitral microscopy analysis, EOOK significantly inhibited carrageenan-induced leukocyte rolling and adhesion. In vitro neutrophils chemotaxis, EOOK inhibited the leukocyte chemotaxis induced by fMLP. Conclusions: The present study showed that EOOK inhibited pain and inflammatory parameters contributing, at least in part, to explain the popular use of this plant as analgesic natural agent. This study also demonstrates that camphor and some known anti-inflammatory compounds present in EOOK could contribute for analgesic and anti-inflammatory articular properties.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul
dc.relation.ispartofJournal of Ethnopharmacology
dc.subjectOcimum kilimandscharicum
dc.titleAnalgesic and anti-inflammatory articular effects of essential oil and camphor isolated from Ocimum kilimandscharicum Gürke leavesen
dc.contributor.institutionFederal University of Grande Dourados
dc.contributor.institutionUniversity Center of Grande Dourados (UNIGRAN)
dc.contributor.institutionFederal University of Mato Grosso do Sul
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.description.affiliationSchool of Health Sciences Federal University of Grande Dourados
dc.description.affiliationSchool of Health Sciences University Center of Grande Dourados (UNIGRAN)
dc.description.affiliationPharmaceutical Sciences Food and Nutrition College Federal University of Mato Grosso do Sul
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Pharmacology and Therapeutics State University of Maringá (UEM)
dc.description.affiliationSchool of Medicine Federal University of Mato Grosso do Sul
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)
dc.description.sponsorshipIdFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul: 59/300.130/2016
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