Percutaneous application of allogeneic adipose-derived mesenchymal stem cell in dogs submitted to minimally invasive plate osteosynthesis of the tibia
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Data
2021-01-01
Autores
Franco, Guilherme Galhardo
Minto, Bruno Watanabe [UNESP]
Dreibi, Rafael Manzini [UNESP]
Costa Junior, Jose Sergio [UNESP]
Gosuen Goncalves Dias, Luis Gustavo [UNESP]
Título da Revista
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Título de Volume
Editor
Acta Cirurgica Brasileira
Resumo
Purpose: To evaluate clinical outcome following minimally invasive plate osteosynthesis (MIPO) associated with percutaneous transplantation of allogeneic adipose-derived mesenchymal stem cells (AD-MSC) at the tibial fracture site in dogs. Methods: Thirty-six dogs presenting with nonarticular complete tibial fracture were included in this study. All fractures were treated by the same MIPO technique. The animals were divided in group 1 (n = 20) received a percutaneous application of 3 x 10(6) AD-MSC at the fracture site and group 2 (n = 16) did not receive any adjuvant treatment. Postoperative radiographic examinations were made at 15, 30, 60, 90 and 120 days. Results: Fifty-eight percent of the patients were classified as skeletally immature. The median weight of the animals was 18.8 kg. The mean radiographic union time differed statistically between the AD-MSC group (28.5 days) and the control group (70.3 days). Sixty percent of dogs in group 1 and 56.25% of the group 2 were considered immature. Conclusion: The use of allogeneic AD-MSC cell therapy and MIPO is a safe, viable and effective technique for promoting bone healing in nonarticular tibial fractures in dogs.
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Palavras-chave
AD-MSC, Fracture Healing, MIPO
Como citar
Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 36, n. 2, 10 p., 2021.