Estudo químico da fração hidroalcoólica de sementes de Aristolochia gigantea (Aristolochiaceae)
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Data
2019-12-11
Autores
Escaliante, Gabriela Anjos de Stefano
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Universidade Estadual Paulista (Unesp)
Resumo
As espécies do gênero Aristolochia (Aristolochiaceae) são conhecidas na medicina popular por serem abortivas, antiofídicas, estomáquicas, anti-inflamatórias, antiasmáticas, antissépticas, expectorantes, sedativas, depurativas, e por ajudarem no emagrecimento. O objetivo deste trabalho foi isolar e identificar os constituintes químicos presentes na fração hidroalcoólica das sementes de Aristolochia gigantea. A fração foi submetida à Cromatografia em Coluna usando Sephadex LH-20 e metanol, o que resultou em doze frações e, posteriormente, no isolamento de quatro substâncias. As estruturas dessas substâncias foram determinadas através experimentos de Ressonância Magnética Nuclear (RMN) uni (1H, 13C) e bidimensionais (HSQC e HMBC) e a configuração absoluta foi atribuída através da medida da rotação específica. No final identificou-se duas lignanas (kobusina e eudesmina), alantoína e um sal inorgânico (KNO3).
The species of Aristolochia genus (Aristolochiaceae) are known in folk medicine for being abortifacients, antiophidics, stomachics, anti-inflammatories, antiasthmatics, antiseptics, expectorants, sedatives, and in slimming therapies. The aim of this work was to isolate and identify de chemical constituents of the hydroalcoholic fraction from the seeds of Aristolochia gigantea. The fractions were submitted to Column Chromatography using Sephadex LH-20 and methanol, led to twelve fractions and the isolation of four compounds. The structures of the compounds were determined by 1D (1H, 13C) and 2D (HSQC e HMBC) NMR techniques and the absolute configuration was attributed by the measurement of the specific rotation. As a result, two lignans (kobusin and eudesmin), alantoine and an inorganic salt (KNO3) were identified.
The species of Aristolochia genus (Aristolochiaceae) are known in folk medicine for being abortifacients, antiophidics, stomachics, anti-inflammatories, antiasthmatics, antiseptics, expectorants, sedatives, and in slimming therapies. The aim of this work was to isolate and identify de chemical constituents of the hydroalcoholic fraction from the seeds of Aristolochia gigantea. The fractions were submitted to Column Chromatography using Sephadex LH-20 and methanol, led to twelve fractions and the isolation of four compounds. The structures of the compounds were determined by 1D (1H, 13C) and 2D (HSQC e HMBC) NMR techniques and the absolute configuration was attributed by the measurement of the specific rotation. As a result, two lignans (kobusin and eudesmin), alantoine and an inorganic salt (KNO3) were identified.
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Palavras-chave
Aristolochia gigantea, Sementes, Lignanas