Infecção experimental por Leishmania (Leishmania) infantum em hamsters: alterações morfofuncionais do cólon.
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Data
2022-01-10
Autores
Chucri, Thaís Martins
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Universidade Estadual Paulista (Unesp)
Resumo
A degradação ambiental e as mudanças climáticas são alguns dos fatores que contribuem para uma maior ocorrência de doenças. Dentre elas, a leishmaniose visceral (LV), uma importante zoonose com letalidade de aproximadamente 95%. É uma infecção sistêmica crônica e quando o parasito atinge o trato gastrointestinal pode provocar alterações morfofisiológicas significativas. No entanto, pouco se sabe sobre o impacto causado por Leishmania no sistema nervoso entérico (SNE). Os neurônios desse plexo desempenham importante papel em manter o peristaltismo e auxiliar na resposta imune do órgão. Diante do exposto e dada a importância do SNE para manter a homeostase do organismo, o objetivo desse estudo foi investigar o comprometimento morfofisiológico das subpopulações de neurônios NADH-dp e NADPH-dp e histopatológico do intestino grosso de hamsters infectados experimentalmente.
Environmental degradation and climate change are some of the factors that contribute to a greater occurrence of diseases. Among them, visceral leishmaniasis (VL), an important zoonosis with a lethality of approximately 95%. It is a chronic systemic infection and when the parasite reaches the gastrointestinal tract it can cause significant morphophysiological changes. However, little is known about the impact of Leishmania on the enteric nervous system (ENS). Neurons in this plexus play an important role in maintaining peristalsis and assisting in the organ's immune response. Given the above and given the importance of the ENS to maintain the homeostasis of the organism, the objective of this study was to investigate the morphophysiological impairment of the subpopulations of NADH-dp and NADPH-dp neurons and the histopathological impairment of the large intestine of experimentally infected hamsters.
Environmental degradation and climate change are some of the factors that contribute to a greater occurrence of diseases. Among them, visceral leishmaniasis (VL), an important zoonosis with a lethality of approximately 95%. It is a chronic systemic infection and when the parasite reaches the gastrointestinal tract it can cause significant morphophysiological changes. However, little is known about the impact of Leishmania on the enteric nervous system (ENS). Neurons in this plexus play an important role in maintaining peristalsis and assisting in the organ's immune response. Given the above and given the importance of the ENS to maintain the homeostasis of the organism, the objective of this study was to investigate the morphophysiological impairment of the subpopulations of NADH-dp and NADPH-dp neurons and the histopathological impairment of the large intestine of experimentally infected hamsters.
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Palavras-chave
Leishmaniose Visceral, Histopatologia, Sistema nervoso entérico, Intestino grosso, Visceral leishmaniasis, Enteric Nervous System, Large intestine, Histopathology