Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 mice
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Data
2021-01-01
Autores
Gouveia, M. C.P. [UNESP]
Minto, B. W. [UNESP]
Sargi, L. F. [UNESP]
Souza, R. L.
Pazzini, J. M.
Colodel, E. M.
Silva, V. C.P.
Cassino, P. C. [UNESP]
Dias, L. G.G.G. [UNESP]
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Resumo
The aim of this study was to evaluate the topical application of alcoholic extracts of Dipteryx alata Vogel almonds and bark in skin wound healing in mice. Fifty-four C57BL/6 mice were equally distributed into three groups: Control, Almond, and Bark. A 9 mm skin fragment was resected from the dorsal region of the animals’ thorax. The wounds were submitted to topical application of base cream (vehicle), 10% hydroalcoholic almond extract, or bark extract twice a day. Macroscopic, histological, and immunohistochemical evaluations were conducted on the 7th, 14th, and 21st postoperative days. No significant difference was observed regarding skin wound area among groups, with the parameter presenting only a temporal effect on healing (p>0.05). The almond and control groups exhibited more intense collagenization than the bark group (p<0.05). Dipteryx alata Vogel showed to be inert in the wound healing process in mice
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Baru, Epithelialization, Leguminosae, Phytotherapic, Skin wounds
Como citar
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 73, n. 6, p. 1315-1322, 2021.