ZIKV B-cell epitopes for immunodiagnostic tests
Abstract
The use of serological tests is valuable to diagnose Zika virus (ZIKV) infection and carry out epidemiological surveillance. However, ZIKV serological tests may result in false positives due to cross-reactivity between antibodies against other Flavivirus, especially dengue virus that worldwide disseminated. We used three online tools to predict amino acid sequences of B-cell epitopes. We selected and synthetized two epitopes that showed appropriate features in the molecular dynamic simulation and demonstrated to be suitable for serological assays.
How to cite this document
Kubiszeski, Janaina Rigotti et al. ZIKV B-cell epitopes for immunodiagnostic tests. Journal of Immunological Methods, v. 504. Available at: <http://hdl.handle.net/11449/223639>.
Language
English
Sponsor
Fundação de Amparo à Pesquisa do Estado de Mato Grosso
Grant number
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