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Crystal structure of Myotoxin-II: A myotoxic phospholipase A2 - homologue from Bothrops moojeni venom

dc.contributor.authorDe Azevedo, W. F. [UNESP]
dc.contributor.authorWard, R. J. [UNESP]
dc.contributor.authorLombardi, F. R. [UNESP]
dc.contributor.authorGiglio, J. R.
dc.contributor.authorSoares, A. M.
dc.contributor.authorFontes, M. R.M. [UNESP]
dc.contributor.authorArni, R. K. [UNESP]
dc.date.accessioned2022-04-28T19:53:19Z
dc.date.available2022-04-28T19:53:19Z
dc.date.issued1997-12-01
dc.identifier.citationProtein and Peptide Letters, v. 4, n. 5, p. 329-334, 1997.
dc.identifier.issn0929-8665
dc.identifier.urihttp://hdl.handle.net/11449/223829
dc.description.abstractThe crystal structure of Myotoxin-II (MjTX-II), a Lys49 PLA2-homologue from Bothrops moojeni venom has been determined and refined at 2.0 Å to a crystallographic residual of 19.7% (Rfree=28.1%). MjTX-II is a dimer in the crystal, with the monomers in the asymmetric unit related by a two-fold symmetry axis running through the dimer interface. The dimers of MjTX-II and the Lys49 PLA2 from B. asper venom are similar, however the relative orientations of the monomers suggests a flexible dimer interface, which serves as a hinge between the two molecules.en
dc.format.extent329-334
dc.language.isoeng
dc.relation.ispartofProtein and Peptide Letters
dc.sourceScopus
dc.titleCrystal structure of Myotoxin-II: A myotoxic phospholipase A2 - homologue from Bothrops moojeni venomen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationDepartment of Physics IBILCE/UNESP, C. P. 136, S. Jose do Rio Preto-SP
dc.description.affiliationDepartment of Biochemistry FMRP/USP, CEP 14-49-900, Ribeirao Preto-SP
dc.description.affiliationDepartment of Biophysics UNESP-Botucatu, Botucatu - SP
dc.description.affiliationUnespDepartment of Physics IBILCE/UNESP, C. P. 136, S. Jose do Rio Preto-SP
dc.description.affiliationUnespDepartment of Biophysics UNESP-Botucatu, Botucatu - SP
dc.identifier.scopus2-s2.0-0001188054
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