Effect of alloxan diabetes and adrenalectomy on carrageenin-induced pleurisy in the rat.
Nenhuma Miniatura disponível
Data
1987-01-01
Autores
Moraes, F. R. [UNESP]
Bechara, G. H. [UNESP]
Moraes, J. R. [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
1. The effect of alloxan diabetes and adrenalectomy on the acute inflammatory response was investigated in rats using the carrageenin-induced pleurisy model. 2. Diabetic rats had reduced exudate volume (-85%) and inflammatory cell accumulation (-50%), especially polymorphonuclear leucocytes (-60%) in the pleural cavity 24 h after stimulation in relation to control values. Subcutaneous insulin administration 2 h after the inflammatory stimulus restored these parameters to normal levels. In contrast, all three measures of the response were potentiated 1.5 to 4-fold in adrenalectomized animals. 3. Results obtained by other investigators using different experimental models point to a possible pro-inflammatory function of insulin for the vascular component of inflammation. The present data show that insulin also has a significant effect on the cellular component of inflammation, especially the polymorphonuclear one, by increasing its accumulation at the affected site.
Descrição
Palavras-chave
Como citar
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 20, n. 1, p. 47-53, 1987.