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dc.contributor.authorNovelli, E. L.B. [UNESP]
dc.contributor.authorRodrigues, N. L. [UNESP]
dc.contributor.authorRibas, B. O. [UNESP]
dc.contributor.authorCuri, P. R. [UNESP]
dc.date.accessioned2022-04-28T19:53:52Z
dc.date.available2022-04-28T19:53:52Z
dc.date.issued1992-01-01
dc.identifierhttp://dx.doi.org/10.1139/y92-091
dc.identifier.citationCanadian Journal of Physiology and Pharmacology, v. 70, n. 5, p. 709-711, 1992.
dc.identifier.issn0008-4212
dc.identifier.urihttp://hdl.handle.net/11449/223936
dc.description.abstractSuperoxide radical (O2-) is a free radical that may be involved in various toxic processes. Cu-Zn superoxide dismutase catalyses the dismutation of the superoxide free radical and protects cells from oxidative damage, and it has been used clinically. The concentration of Ni2+ and Cu-Zn superoxide dismutase activity were measured in lungs of rats at time intervals of 5, 12, 19, 26, 33, and 40 days following an intratracheal injection of 127 nmol of NiCl2. Nickel chloride increased nickel content and resulted in a significant increase of Cu-Zn superoxide dismutase activity in lungs. This elevation of Cu-Zn superoxide dismutase activity was highest on the 12th day (approximately threefold) and is at levels comparable to controls rats on day 40 onwards. Since Cu-Zn superoxide dismutase activity was increased in lung throughout our experimental period without corresponding increases of Cu2+ and Zn2+, we speculate that the elevation of Cu-Zn superoxide dismutase activity might be due to an increased half-life of the enzyme, induced by nickel.en
dc.format.extent709-711
dc.language.isoeng
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology
dc.sourceScopus
dc.subjectCu-Zn superoxide dismutase
dc.subjectintratracheal
dc.subjectlung
dc.subjectnickel chloride
dc.titleIntrathracheal injection of nickel chloride and copper-zinc superoxide dismutase activity in lung of ratsen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartamento de Quimica Instituto de Biociencias Universidade Estadual Paulista, 18610 Botucatu
dc.description.affiliationUnespDepartamento de Quimica Instituto de Biociencias Universidade Estadual Paulista, 18610 Botucatu
dc.identifier.doi10.1139/y92-091
dc.identifier.scopus2-s2.0-0026616942
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