Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4nanoparticles
Nenhuma Miniatura disponível
Data
2021-10-01
Autores
Prospero, Andre Gonçalves [UNESP]
Buranello, Lais Pereira [UNESP]
Fernandes, Carlos Ah [UNESP]
Dos Santos, Lucilene Delazari [UNESP]
Soares, Guilherme [UNESP]
C Rossini, Bruno [UNESP]
Zufelato, Nícholas
Bakuzis, Andris Figueiroa
De Mattos Fontes, Marcos R [UNESP]
De Arruda Miranda, José R [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Background: We evaluated the impacts of corona protein (CP) formation on the alternating current biosusceptometry (ACB) signal intensity and in vivo circulation times of three differently coated magnetic nanoparticles (MNP): bare, citrate-coated and bovine serum albumin-coated MNPs. Methods: We employed the ACB system, gel electrophoresis and mass spectrometry analysis. Results: Higher CP formation led to a greater reduction in the in vitro ACB signal intensity and circulation time. We found fewer proteins forming the CP for the bovine serum albumin-coated MNPs, which presented the highest circulation time in vivo among the MNPs studied. Conclusion: These data showed better biocompatibility, stability and magnetic signal uniformity in biological media for bovine serum albumin-coated MNPs than for citrate-coated MNPs and bare MNPs.
Descrição
Palavras-chave
alternating current biosusceptometry, biomedical engineering, corona protein, magnetic nanoparticles, mass spectrometry
Como citar
Nanomedicine, v. 16, n. 24, p. 2189-2206, 2021.