Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells
Nenhuma Miniatura disponível
Data
2022-02-01
Autores
Pagnan, Ana Lígia
Pessoa, Adriano Souza
Tokuhara, Cintia Kazuko
Fakhoury, Vanessa Svizzero
Oliveira, Gabriela Silva Neubern
Sanches, Mariana Liessa Rovis
Inacio, Kelly Karina
Ximenes, Valdecir Farias [UNESP]
Oliveira, Rodrigo Cardoso
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Osteosarcoma is the most common type of bone cancer, and metastasis is widespread decreasing the survival rate. The search for new therapeutic strategies has increased for phytochemicals due to their potential as antioxidants and anticancer properties. Thus, we evaluated the caffeic acid phenethyl ester (CAPE) and caffeic acid's (CA) anticancer properties on UMR-106 murine osteosarcoma cells. The IC25 and IC50 were 1.3 and 2.7 μM for CAPE and 91.0 and 120.0 μM for CA, respectively. This study shows the potential anticancer properties of CAPE and highlights how a phenethyl ester component addition can improve the pharmacological potency in relation to its precursor CA. Our results showed that CAPE was more efficient and selective in reducing the viability of tumor cells compared to the control osteoblasts (MC3T3-E1) (p < 0.05). In addition, CAPE was 44-fold (IC25) and 70-fold (IC50) more cytotoxic than CA. CAPE also decreased ROS generation and cell migration. In summary, CAPE was more selective for tumor cells, preserving normal ones, suggesting its potential role as an anticancer drug.
Descrição
Palavras-chave
Antioxidants, Cancer, Cytotoxicity, Phenolic compounds, Phytochemicals
Como citar
Tissue and Cell, v. 74.