Dereplication of extracts from nutraceutical mushrooms pleurotus using molecular network approach
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Data
2022-02-15
Autores
Caldas, Lhaís Araújo
Zied, Diego Cunha [UNESP]
Sartorelli, Patrícia
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Resumo
Pleurotus is an edible mushroom from the well-known genus of Basidiomycetes; it is the second-most commonly consumed mushroom worldwide. This genus is characterized by the presence of steroids, fatty acids, and polysaccharides. Recently, Pleurotus has become popular as a functional food owing to its health benefits, primarily because they are a source of vitamins, fibers, minerals, and lipids. In natural products chemistry, dereplication techniques identify bioactive molecules from natural sources such as plants and fungi without isolating or characterizing molecules. We used dereplication techniques aided by the Global Natural Products Social Molecular Network to analyze the chemical composition of the methanolic extracts of six Pleurotus species (P. sapidus, P. ostreaus, P. ostreaus var. Florida, P. djamor, P. citrinopileatus, and P. pulmonarius), to identify bioactive molecules with nutraceutical properties. Using this technique, we identified several molecular families, including eight fatty acids and seven steroids. Our findings suggest that dereplication is a relatively rapid tool for characterizing fungal species and determining their nutraceutical value.
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Basidiomycetes, Fatty acid, GNPS, Nutraceutical value, Steroid
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Food Chemistry, v. 370.