Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by Paracoccidioides sp.
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Data
2022-05-01
Autores
Krakhecke-Teixeira, Alessandra G.
Yamauchi, Danielle H. [UNESP]
Rossi, Alexsandra
de Sousa, Herdson R.
Garces, Hans G. [UNESP]
Júnior, Joaquim L.
Júnior, Antônio O. S.
Felipe, Maria Sueli S.
Bagagli, Eduardo [UNESP]
de Andrade, Heitor F.
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Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Brazil. The disease is caused by dimorphic fungi nested within the Paracoccidioides genus. We described 106 PCM cases (47.1 cases/year) at the Tropical Diseases Public Hospital of Tocantins State. PCM was prevalent in males and rural workers over 50 years; the chronic pulmonary form predominated in 67% of cases. The male-to-female ratio was 2.65:1, with more women affected than other endemic regions of Brazil. Urban or indoor activities were reported in women and are ascribed to disease urbanization. qPCR-based assays confirmed the identification of Paracoccidioides DNA in 37 biological specimens. Paracoccidioides sp. DNA was found in 53% of the environmental samples, suggesting autochthonous infections. Therefore, the Tocantins-Araguaia basin must be considered a novel hyperendemic area of PCM in Brazil, reinforcing the importance of including PCM as a notifiable disease, requiring specific diagnosis and health measures.
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Northern Brazil, paracoccid-ioidomycosis, Paracoccidioides brasiliensis, Paracoccidioides lutzii, Tocantins-Araguaia basin
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Journal of Fungi, v. 8, n. 5, 2022.