Using thermal and spectroscopic data to investigate the thermal behavior of epinephrine
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Data
2010-02-20
Autores
Bannach, Gilbert [UNESP]
Cervini, Priscila
Gomes Cavalheiro, Eder Tadeu
Ionashiro, Massao [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
Epinephrine is a neurotransmitter of the catecholamine class that acts in the mammalian central nervous system. The TG-DTA curves of epinephrine showed that the anhydrous compound starts decomposition at 165 degrees C, under the conditions used in this work. The reflectance FTIR spectra and X-ray powder diffraction patterns of epinephrine before and after heating up to 210 degrees C, as well as the TG-FTIR spectra of sample heated between 30 and 600 degrees C, were obtained and reveled that after heating, structural changes occurred in the sample. At temperatures higher than 205 degrees C the thermal decomposition took place with elimination of rnethylamine in agreement with the first mass loss observed in the TG curve in both air and N(2) atmospheres (TG = 17.0%, calcd. = 17.0%). The melting was observed at 205 degrees C (DTA) or 203 degrees C (DSC) but this process occurred overlapped with decomposition characteristic of an incongruent melting process. (C) 2009 Elsevier B.V. All rights reserved.
Descrição
Palavras-chave
Epinephrine, Thermal decomposition, Thermal stability, TG-FTIR, TG-DTA
Como citar
Thermochimica Acta. Amsterdam: Elsevier B.V., v. 499, n. 1-2, p. 123-127, 2010.