Publicação: Cytotoxic Clerodane Diterpenoids from Casearia obliqua
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Amer Chemical Soc
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
A crude bioactive EtOH extract of the twigs of Casearia obliqua afforded two new clerodane diterpenes, caseobliquins A (1) and B (2). Additionally, bioactivity-directed fractionation on a bioactive hexane extract of the leaves from this species led. to the isolation of the known clerodane diterpenes rel-6 beta-hydroxyzuelanin-2 beta-benzoate and rel-2 alpha-hydroxyzuelanin-6 beta-benzoate (3 and 4) as a mixture and 2 beta-hydroxyzuelanin-6 beta-cinnamate (5). The structures of the new clerodanes 1 and 2 were established on the basis of their 1D and 2D NMR spectroscopic data, and the new compound I and the known substance 5 had their absolute configurations determined by circular dichroism spectroscopy. The cytotoxicity of several of the compounds isolated was evaluated against a small panel of human tumor cell lines.
Descrição
Palavras-chave
Idioma
Inglês
Como citar
Journal of Natural Products. Washington: Amer Chemical Soc, v. 72, n. 10, p. 1847-1850, 2009.
