Avaliação da prevalência da infecção por helicobacter pylori em pacientes portadores de câncer gástrico
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Data
2003-02-01
Autores
Rangel, Marcelo Fernandes
Amorim, Waldir Pedrosa de
Amorim, Maria de Fátima Duques de
Amorim, Pedro Duques de [UNESP]
Nóbrega, Leonardo Pires de Sá
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ISSN da Revista
Título de Volume
Editor
Colégio Brasileiro de Cirurgiões
Resumo
OBJETIVO: Nos últimos anos, evidências de associação entre Helicobacter pylori e câncer gástrico têm sido relatadas por inúmeros estudos. Este trabalho objetiva investigar a prevalência da infecção por este microorganismo em pacientes com câncer gástrico, oriundos do Hospital de Câncer Napoleão Laureano (João Pessoa - PB) e determinar o risco relativo para o desenvolvimento desta neoplasia nos pacientes infectados. MÉTODO: Com esta finalidade, 16 pacientes com diagnóstico confirmado de adenocarcinoma gástrico foram submetidos à endoscopia digestiva alta para coleta de fragmentos da mucosa gástrica, para realização do teste da urease, sendo então, pareados com um grupo de 16 controles com exames endoscópicos normais. RESULTADOS: Dos 16 portadores de câncer, 28,1% estavam infectados, versus 25% para os do grupo controle. Nos indivíduos infectados, houve maior prevalência da infecção nos portadores de lesões gástricas distais (43,8%), nos tumores Borrmann III (37,6%), e moderadamente diferenciados (37,6%). Houve associação estatisticamente significante entre o grau de diferenciação e a presença da infecção pelo H. pylori (p<0,10). O risco relativo estimado para a associação entre câncer gástrico e infecção pelo H. pylori foi de 1,28% (odds ratio = 1,28%). CONCLUSÃO: Estes resultados permitem concluir que a infecção pelo H. pylori é um fator de risco relativo para o desenvolvimento do adenocarcinoma gástrico.
BACKGROUND: In recent years evidence of the association between Helicobacter pylori and gastric cancer has been related by many studies. This work aims both at investigating the prevalence of infection by this micro-organism in patients with gastric cancer from Cancer Hospital Napoleão Laureano (João Pessoa - PB) and at determining the relative risk to the development of this neoplasm in infected patients. METHODS: Sixteen patients with confirmed diagnostic of gastric adenocarcinoma were submited to a high digestive endoscopy so that fragments of the stomach were paired with a group of sixteen controls with normal endoscopic exams. RESULTS: of the sixteen patients with cancer, 28,1% were infected versus 25% of the control group. Within infected patients, H. pylori was more prevalent among those with distal gastric lesions (43,8%), in Borrmann III (37,6%) and moderately differentiated tumors(37,6%). There was a statistically significant association between the degree of differentiation and the presence of the infection by the H. Pylori (p < 0,10). The estimated relative risk of the association between gastric cancer and H. Pylori infection was 1,28% (odds ratio = 1,28%). CONCLUSION: Based on these results we can conclude that H. Pylori infection is a factor of relative risk for the development of gastric adenocarcinoma.
BACKGROUND: In recent years evidence of the association between Helicobacter pylori and gastric cancer has been related by many studies. This work aims both at investigating the prevalence of infection by this micro-organism in patients with gastric cancer from Cancer Hospital Napoleão Laureano (João Pessoa - PB) and at determining the relative risk to the development of this neoplasm in infected patients. METHODS: Sixteen patients with confirmed diagnostic of gastric adenocarcinoma were submited to a high digestive endoscopy so that fragments of the stomach were paired with a group of sixteen controls with normal endoscopic exams. RESULTS: of the sixteen patients with cancer, 28,1% were infected versus 25% of the control group. Within infected patients, H. pylori was more prevalent among those with distal gastric lesions (43,8%), in Borrmann III (37,6%) and moderately differentiated tumors(37,6%). There was a statistically significant association between the degree of differentiation and the presence of the infection by the H. Pylori (p < 0,10). The estimated relative risk of the association between gastric cancer and H. Pylori infection was 1,28% (odds ratio = 1,28%). CONCLUSION: Based on these results we can conclude that H. Pylori infection is a factor of relative risk for the development of gastric adenocarcinoma.
Descrição
Palavras-chave
Helicobacter pylori, Câncer Gástrico, Infecção, Prevalência, Helicobacter pylori, Gastric cancer, Infection, Prevalence
Como citar
Revista do Colégio Brasileiro de Cirurgiões. Colégio Brasileiro de Cirurgiões, v. 30, n. 1, p. 34-42, 2003.