Uso da ciclofosfamida em modelo de imunodepressão experimental em ovinos
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Data
2004-07-01
Autores
Garcia, M.
Sertorio, S. P.
Alves, G. J.
Chate, S. C.
Carneiro, R.
Lallo, M. A.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Revista Pesquisa Veterinaria Brasileira
Resumo
Cyclophosphamide (CY) was used to evaluate the effect on the immune system of sheep. Castred adult rams were divided into 3 groups, with 6 animals each one. Group I (day 0) and Group II (day 1) were treated with CY (40 mg/kg, single dose, IV), and Group III was not treated and remained as control. All groups were immunized on day 0 with B19 brucellosis vaccine. on day 6, all animals were bled and serum agglutination test for brucellosis antibodies detection was performed. During 7 days blood lymphocyte counts and electrophoresis gammaglobulin dosage were daily performed. The results showed statistical decrease of immune response. Low serum titers of brucellosis antibodies were found in Groups I and II, and lymphopenia and hypogammaglobulinemia were also found in these groups. A high mortality rate (40%) occurred in the treated animals.
Descrição
Palavras-chave
immunosupression, cyclophosfamide, immunology, sheep
Como citar
Pesquisa Veterinaria Brasileira. Rio Janeiro: Revista Pesquisa Veterinaria Brasileira, v. 24, n. 3, p. 115-119, 2004.