Effects of central alpha-adrenergic agonists on hormone-induced 3% NaCl and water intake
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Data
1996-08-23
Autores
Paula, Patricia Maria de [UNESP]
Sato, M. A.
Menani, José Vanderlei [UNESP]
DeLuca, L. A.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
Male rats received intracerebroventricular (ICV) renin (600 ng) or daily subcutaneous injections of deoxycorticosterone (5 mg) to induce 3% NaCl and water intake. Noradrenaline (NOR; 40-160 nmol) and clonidine (CLO; 5-20 nmol) injected ICV. induced 70 to 100% inhibition of the intakes. Phenylephrine (PHE; 40-160 nmol) injected ICV induced 60 to 95% inhibition of the intakes. NOR and PHE induced a stronger inhibition on the 3% NaCl intake induced by renin than on the intake induced by deoxycorticosterone (DOC), and CLO did the opposite. CLO was always more effective than PHE to induce inhibition of the intakes. The results suggest that NOR inhibits hormone (angiotensin II, aldosterone)-induced NaCl intake by acting mainly on alpha(2)-adrenergic receptors.
Descrição
Palavras-chave
noradrenaline, clonidine, phenylephrine, angiotensin II, aldostereone, adrenoceptors
Como citar
Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 214, n. 2-3, p. 155-158, 1996.