Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae
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Data
2005-01-01
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Editor
Acad Sciences Czech Republic, Inst Physiology
Resumo
In this study we investigated the effect of beta-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 mu g of glucan by i.p. route, were assayed. In vivo mu-glucan administration primed spleen cells for a higher production of IL-12 and TNF-alpha when S. aureus was used as a stimulus. In addition, beta-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for beta-glucan were observed in this work.
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Palavras-chave
beta-glucan, IL-12, TNF-alpha, NK activity, fungicidal activity
Como citar
Physiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 54, n. 5, p. 557-564, 2005.