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dc.contributor.authorBordon, Ana Paula
dc.contributor.authorDias-Melicio, Luciane Alarcao
dc.contributor.authorAcorci-Valerio, Michele Janegitz [UNESP]
dc.contributor.authorCalvi, Sueli Aparecida
dc.contributor.authorSerrao Peracoli, Maria Terezinha
dc.contributor.authorVictoriano de Campos Soares, Angela Maria
dc.date.accessioned2014-05-20T15:24:45Z
dc.date.available2014-05-20T15:24:45Z
dc.date.issued2007-05-01
dc.identifierhttp://dx.doi.org/10.1016/j.micinf.2007.02.019
dc.identifier.citationMicrobes and Infection. Amsterdam: Elsevier B.V., v. 9, n. 6, p. 744-747, 2007.
dc.identifier.issn1286-4579
dc.identifier.urihttp://hdl.handle.net/11449/35307
dc.description.abstractHuman monocytes lacked fungicidal activity against high virulence strain of Paracoccidioides brasiliensis, even after IFN-gamma activation. However, monocytes treated with indomethacin exhibited an effective killing against this fungus, suggesting a role of prostaglandin E-2 (PGE(2)) in the inhibition process. Thus, the purpose of this work was to determine whether the effect of PGE2 in fungicidal activity was related with decrease on H2O2 release, the metabolite involved in P. brasiliensis killing, and changes in the levels of TNF-alpha, IL-6 and IL-10. Human monocytes challenged with the fungus produced high PGE(2) levels, which in turn inhibited the fungicidal activity of these cells by reducing H2O2 and TNF-alpha production. (C) 2007 Elsevier Masson SAS. All rights reserved.en
dc.format.extent744-747
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMicrobes and Infection
dc.sourceWeb of Science
dc.subjectprostaglandin E-2pt
dc.subjectH2O2pt
dc.subjectcytokinespt
dc.subjectmonocytespt
dc.subjectParacoccidioides brasiliensispt
dc.titleProstaglandin E-2 inhibits Paracoccidioides brasiliensis killing by human monocytesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationUniv Estadual Paulista, Inst Biosci, Dept Microbiol & Immunol, BR-18618000 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucantu Med Sch, Dept Trop Dis & Image Diagnosis, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biosci, Dept Microbiol & Immunol, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucantu Med Sch, Dept Trop Dis & Image Diagnosis, BR-18618000 São Paulo, Brazil
dc.identifier.doi10.1016/j.micinf.2007.02.019
dc.identifier.wosWOS:000246980500008
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.author.orcid0000-0003-1962-9901[6]
unesp.author.orcid0000-0001-9254-2074[2]
dc.relation.ispartofjcr2.924
dc.relation.ispartofsjr1,205
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