Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue - Type A with a high prevalence of deletions within the latent membrane protein gene
Nenhuma Miniatura disponível
Data
1996-01-01
Autores
Chen, W. G.
Chen, Y. Y.
Bacchi, M. M.
Bacchi, C. E.
Alvarenga, M.
Weiss, L. M.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Amer Soc Investigative Pathology, Inc
Resumo
Both Epstein-Barr virus (EBV) types A and B are found in endemic Burkitt's lymphoma (BL) occurring in equatorial Africa. We studied 17 cases of Brazilian BL previously demonstrated to be EBV-positive to determine the EBV type as well as the presence of a characteristic 30 bp deletion within the 3' end of the latent membrane protein-1 (LMP-1) gene that may be important to the pathogenesis of several EBV-associated neoplasms. All case in which the age was known were children. We found type A EBV in 13 of 14 (93%) evaluable cases, and type B in one case. The LMP-1 deletion was found in 12 of 15 (80%) evaluable cases, including the one case of type B EBV, and a similar high prevalence (59%) of the deletion was detected in EBV-positive normal and reactive lymphoid tissues from individuals from the same geographic region. The high proportion of cases associated with type A EBV suggests that immunodeficiency is not an important factor in the pathogenesis of Brazilian BL, in contrast to endemic African BL. The presence of the LMP-1 deletion in a high prevalence in the normal population in this region is unexplained.
Descrição
Palavras-chave
Como citar
American Journal of Pathology. Baltimore: Amer Soc Investigative Pathology, Inc., v. 148, n. 1, p. 17-23, 1996.