Publicação: Potentiometric determination of alendronate in pharmaceutical formulations
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Instytut Chemii Fizycznej Pan
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
A simple, precise, fast and low-cost potentiometric method for alendronate determination in pharmaceutical formulations has been proposed. Alendronate present in tablets at the known concentration was potentiometrically titrated in an aqueous solution using a combined glass electrode coupled with an autotitrator. Determination limit of alendronate was 20.0 mug mL(-1). In the presence of common excipients, such as lactose, microcrystalline cellulose, glucose, croscarmellose sodium, starch, talc, magnesium stearate and titanium dioxide no interferences were observed. The method proposed was validated by determining alendronate in various dosage forms. The average RSD was 0.75%.
Descrição
Palavras-chave
potentiometric determination, alendronate, pharmaceutical formulations
Idioma
Inglês
Como citar
Chemia Analityczna. Warsaw: Instytut Chemii Fizycznej Pan, v. 49, n. 3, p. 351-357, 2004.
