Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp
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Data
2012-06-01
Autores
Gontijo, Vanessa Silva
de Souza, Thiago Correa
Rosa, Isael Aparecido
Soares, Marisi Gomes
da Silva, Marcelo Aparecido
Vilegas, Wagner [UNESP]
Viegas Junior, Claudio
dos Santos, Marcelo Henrique
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Editor
Elsevier B.V.
Resumo
A new glycosylated biflavonone, morelloflavone-4 '''-O-beta-D-glycosyl, and the known compounds 1,3,6,7-tetrahydroxyxanthone, morelloflavone (fukugetin) and morelloflavone-7 ''-O-beta-D-glycosyl (fukugeside) were isolated from the epicarp of Garcinia brasiliensis collected in Brazil. The structures of these compounds were established using H-1 and C-13 NMR, COSY, gHMQC and gHMBC spectroscopy. The compounds exhibited antioxidant activity. The greatest potency was displayed by morelloflavone (2), with IC50 = 49.5 mM against DPPH and absorbance of 0.583 at 400 mu g/mL for the reduction of Fe3+. The weakest potency was displayed by 1,3,6,7-tetrahydroxyxanthone (1), with IC50 = 148 mM against DPPH and absorbance of 0.194 at 400 mu g/mL for the reduction of Fe3+. (C) 2011 Elsevier Ltd. All rights reserved.
Descrição
Palavras-chave
Garcinia brasiliensis, Biflavonoids, Natural products, Antioxidants
Como citar
Food Chemistry. Oxford: Elsevier B.V., v. 132, n. 3, p. 1230-1235, 2012.