Publicação: Bioactive guanidine alkaloids from Pterogyne nitens
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Resumo
Bioactivity-guided fractionation of a methanolic CHCl 3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC 12=9.3-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B 1 cells (IC 50=8.5-13.0 μg/ml).
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guanidine derivative, nitensidine, pterogynidine, pterogynine, unclassified drug, antineoplastic activity, bioassay, carbon nuclear magnetic resonance, cytotoxicity, dna repair, drug activity, drug isolation, drug structure, proton nuclear magnetic resonance
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Inglês
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Journal of Natural Products, v. 58, n. 11, p. 1683-1688, 1995.
