Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent
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Data
2003-08-01
Autores
Spolidório, Luis Carlos [UNESP]
Spolidorio, D. M.
Benatti, C.
Sampaio, J. E.
Almeida, O. P.
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Resumo
Background: Cyclosporin A and nifedipine cause gingival overgrowth in rat, and the combined use of these drugs increases the overgrowth severity. Objective: The purpose of this study was to compare gingival overgrowth of rats of differents ages treated with cyclosporin A and nifedipine alone or given concurrently. Materials and methods: Rats 15, 30, 60 and 90 d old were treated with 10 mg/kg body weight of cyclosporin A and/or 50 mg/kg body weight of nifedipine in the chow. Results: Young rats showed evident gingival overgrowth with nifedipine, cyclosporin A, and cyclosporin A and nifedipine given concurrently. Adult rats did not show significant gingival alterations when treated with cyclosporin A and nifedipine alone. Nevertheless evident gingival overgrowth with alterations of the epithelium and connective tissue were observed when treated simultaneously with cyclosporin A and nifedipine. Conclusion: These results suggest that the combined effects of cyclosporin A and nifedipine on gingival overgrowth in rat is not age dependent.
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Age, Cyclosporin A, Gingival overgrowth, Nifedipine, cyclosporin, nifedipine, calcium channel blocking agent, immunosuppressive agent, age, animal experiment, animal model, animal tissue, connective tissue, controlled study, drug effect, gingiva hyperplasia, male, mouth mucosa, nonhuman, rat, analysis of variance, animal, chemically induced disorder, comparative study, drug combination, drug potentiation, epithelium, gingiva overgrowth, Wistar rat, Age Factors, Analysis of Variance, Animals, Calcium Channel Blockers, Connective Tissue, Cyclosporine, Drug Combinations, Drug Synergism, Epithelium, Gingival Overgrowth, Immunosuppressive Agents, Male, Rats, Rats, Wistar
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Journal of Periodontal Research, v. 38, n. 4, p. 375-379, 2003.