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dc.contributor.authorFioretto, José Roberto [UNESP]
dc.date.accessioned2014-05-27T11:20:55Z
dc.date.available2014-05-27T11:20:55Z
dc.date.issued2003-11-01
dc.identifierhttp://dx.doi.org/10.1590/S0021-75572003000800007
dc.identifier.citationJornal de Pediatria, v. 79, n. SUPPL. 2, 2003.
dc.identifier.issn0021-7557
dc.identifier.urihttp://hdl.handle.net/11449/67460
dc.description.abstractObjective: To review the literature on inhaled nitric oxide and to describe its main clinical applications in pediatrics. Sources of data: A 10 year literature review with selection of the most important publications on inhaled nitric oxide, using the Medline and Cochrane Systematic Review databases. Summary of the findings: This review was organized as follows: introduction; metabolism and biological effects; clinical applications; dosage, gas administration and weaning; precautions and side-effects. Inhaled nitric oxide use was described in persistent pulmonary hypertension and hypoxia of the newborn, acute respiratory distress syndrome, primary pulmonary hypertension, heart surgery, chronic obstructive pulmonary disease, sickle cell anemia, and bronchospastic disease. Conclusions: Inhaled nitric oxide is a therapeutic approach with wide clinical applications in pediatrics. Its use is safe when administered in pediatric intensive care units under strict monitoring. As a pulmonary vasodilator, nitric oxide has beneficial effects on gas exchange and ventilation. Controlled trials, focusing on early gas administration should be performed under many clinical conditions, especially acute respiratory distress syndrome.en
dc.language.isopor
dc.relation.ispartofJornal de Pediatria
dc.sourceScopus
dc.subjectInhaled nitric oxide
dc.subjectMechanical ventilation
dc.subjectPediatrics
dc.subjectPulmonary hypertension
dc.subjectcorticosteroid
dc.subjectdobutamine
dc.subjectdopamine
dc.subjectnitric oxide
dc.subjectsurfactant
dc.subjectbronchospasm
dc.subjectchronic obstructive lung disease
dc.subjectcongenital heart disease
dc.subjectdata analysis
dc.subjectdrug effect
dc.subjectdrug mechanism
dc.subjectdrug metabolism
dc.subjectdrug safety
dc.subjectdrug screening
dc.subjectdrug utilization
dc.subjectheart surgery
dc.subjectheart transplantation
dc.subjecthuman
dc.subjectinhalation
dc.subjectmedical information
dc.subjectmethemoglobinemia
dc.subjectnewborn hypoxia
dc.subjectpulmonary hypertension
dc.subjectrespiratory distress syndrome
dc.subjectreview
dc.subjectsickle cell anemia
dc.subjectside effect
dc.subjecttreatment contraindication
dc.subjecttreatment indication
dc.subjectweaning
dc.subjectAdministration, Inhalation
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectHumans
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectIntensive Care
dc.subjectLung Diseases
dc.subjectNitric Oxide
dc.subjectVasodilator Agents
dc.titleUso do óxido nítrico em pediatriapt
dc.title.alternativeInhaled nitric oxide in pediatricsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jped/paboutj.htm
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationUNESP Faculdade de Medicina de Botucatu Dep. Pediatria, CEP 18618-970 - Botucatu - SP
dc.description.affiliationUnespUNESP Faculdade de Medicina de Botucatu Dep. Pediatria, CEP 18618-970 - Botucatu - SP
dc.identifier.doi10.1590/S0021-75572003000800007
dc.identifier.scieloS0021-75572003000800007
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-0348225443
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
dc.identifier.file2-s2.0-0348225443.pdf
dc.relation.ispartofjcr1.690
dc.relation.ispartofsjr0,704
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