O emprego de hormônio luteinizante recombinante associado ao hormônio folículo-estimulante recombinante nos protocolos de estimulação ovariana com antagonista do GnRH
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Data
2006-10-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
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Tipo
Artigo
Direito de acesso
Acesso aberto
Resumo
The purpose of this investigation was to verify the efficacy of recombinant LH supplementation for controlled ovarian stimulation in GnRH-antagonist protocol for assisted reproductive technologies cycles. Search strategies included on-line surveys of databases from 1990 to 2006. In this review and meta-analysis, the observed advantages for the LH supplementation protocol were a higher serum estradiol levels on the day of hCG administration and a higher number of mature oocytes. However, there were no differences observed in the total amount of r-FSH administered, days of stimulation, number of oocyte retrieved, the clinical pregnancy rate per oocyte retrieval, the implantation rate and miscarriage rate. This result demonstrates that the association of r-LH with r-FSH may prevent any decrease in estradiol after antagonist administration and a significant higher number of mature oocytes was obtained. Nevertheless, additional randomized controlled trials are needed confirm these observations.
Descrição
Palavras-chave
GnRH antagonist , Ovarian stimulation , Recombinant FSH , Recombinant LH , cetrorelix , chorionic gonadotropin , estradiol , ethinylestradiol , ethinylestradiol plus gestodene , gonadorelin antagonist , levonorgestrel , oral contraceptive agent , recombinant follitropin , recombinant luteinizing hormone , clinical trial , combination chemotherapy , data base , drug dose regimen , drug efficacy , drug mechanism , estradiol blood level , hormone substitution , human , low drug dose , meta analysis , monotherapy , oocyte , ovary function , pregnancy rate , spontaneous abortion , systematic review
Idioma
Português
Como citar
Jornal Brasileiro de Reproducao Assistida, v. 10, n. 4, p. 9-16, 2006.