Daytime variations in glucose tolerance in people with impaired glucose tolerance
MetadataShow full item record
To determine whether glucose tolerance varies throughout the day in people with impaired glucose tolerance (IGT). We studied 15 healthy IGT, and 18 matched normal glucose tolerant (NGT) individuals. Blood samples were taken every 30-120 min during a 24 h period in which all individuals had three mixed meals and nocturnal sleep. We measured glucose, free fatty acids, specific insulin, intact proinsulin, cortisol and growth hormone. Variable responses were considered as concentrations and areas under the curves. Comparison between the groups was by Student's t-test, Mann-Whitney, and analysis of variance. Higher total glucose response, inappropriate normal total insulin response, and unproportionally increased proinsulin total response were observed in the IGT group. Lower glucose tolerance occurred in IGT after dinner, as in the NGT, and after breakfast associated with increased insulin response after breakfast, and similar proinsulin response after all three meals. IGT had higher glucose response than NGT after breakfast and lunch, similar insulin responses, and increased proinsulin-insulin ratio after all three meals. Data from this study demonstrate that IGT individuals present lower glucose tolerance in the evening, as those with NGT, and in the morning, as reported in patients with type 2 diabetes. © 2006 Elsevier B.V. All rights reserved.
How to cite this document
Showing items related by title, author, creator and subject.
Acute exercise decreases PTP-1B protein level and improves insulin signaling in the liver of old rats de Moura, Leandro Pereira ; Souza Pauli, Luciana Santos; Cintra, Dennys Esper; de Souza, Claudio Teodoro; da Silva, Adelino Sanchez Ramos; Marinho, Rodolfo; de Melo, Maria Alice Rostom ; Ropelle, Eduardo Rochete; Pauli, José Rodrigo (Immunity and Ageing, 2013) [Artigo]It is now commonly accepted that chronic inflammation associated with obesity during aging induces insulin resistance in the liver. In the present study, we investigated whether the improvement in insulin sensitivity and ...
Pimenta, W. P. ; Rudge, Marilza Vieira Cunha ; Aragon, F. F. ; Padovani, Carlos Roberto (Diabetes Research and Clinical Practice, 2004) [Artigo]We evaluated insulin release and insulin sensitivity in women with basal and/or postprandial hyperglycemia but normal oral glucose tolerance test (OGTT) in previous pregnancy (GHG). These women were individually matched ...
HIPERTENSAO ARTERIAL EM PACIENTES OBESOS COM HIPERTROFIA CARDIACA. EFEITOS DO CAPTOPRIL SOBRE A SENSIBILIDADE A INSULINA E HORMONIO DE CRESCIMENTO Velasco-Conejo, I. F. ; Martin, Luis Cuadrado ; Brandao-Neto, J. ; Marchioli, M. ; De Barros e Silva, M. ; De Cassia Athanazio-Heliodoro, R. ; Da Silva Franco, R. J. (Arquivos Brasileiros de Cardiologia, 1995) [Artigo]Purpose. To evaluate the effects of captopril (Cpt) on carbohydrate metabolism and growth hormone (GH) in adults hypertensive obese patients with normal (NGT) or impaired (IGT) glucose tolerance and left ventricular ...