Mandible metastasis as the first sign from primary adenocarcinoma of the lung
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Data
2007-05-01
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Adenocarcinoma of the lung that metastasizes to the mandible is very uncommon; only a few cases have been described in the English-language literature. This article presents a metastasis from adenocarcinoma of the lung affecting the mandible of a 64-year-old woman, in which the first discovered metastatic lesion was detected before the primary tumor. The immunoreactivity for human thyroid transcription factor-1 (TTF-1) in the oral lesion was essential for determining the site and type of the primary tumor, as the patient showed no clinical or radiographic evidence of a tumor in the thyroid gland. After the primary tumor in the lung was diagnosed, radiotherapy and chemotherapy were initiated; unfortunately, the patient died two months after the start of treatment. This article emphasizes the importance of a well-conducted examination for diagnosing metastatic oral lesions.
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homeodomain protein, nuclear protein, thyroid nuclear factor 1, transcription factor, unclassified drug, adenocarcinoma, case report, fatality, female, human, lung tumor, mandible tumor, metastasis, middle aged, pathology, skull tumor, Adenocarcinoma, Fatal Outcome, Female, Homeodomain Proteins, Humans, Lung Neoplasms, Mandibular Neoplasms, Middle Aged, Nuclear Proteins, Skull Neoplasms, Transcription Factors
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General Dentistry, v. 55, n. 3, p. 224-227, 2007.