In vivo preservation of the hybrid layer by chlorhexidine
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Data
2007-06-01
Autores
Carrilho, M. R. O.
Geraldeli, S.
Tay, F.
Goes, M. F. de
Carvalho, R. M.
Tjäderhane, L.
Reis, A. F.
Hebling, J.
Mazzoni, A.
Breschi, L.
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Resumo
Host-derived proteases have been reported to degrade the collagen matrix of incompletely-resin-infiltrated dentin. This study tested the hypothesis that interfacial degradation of resin-dentin bonds may be prevented or delayed by the application of chlorhexidine (CHX), a matrix metalloproteinase inhibitor, to dentin after phosphoric acid-etching. Contralateral pairs of resin-bonded Class I restorations in non-carious third molars were kept under intra-oral function for 14 months. Preservation of resin-dentin bonds was assessed by microtensile bond strength tests and TEM examination. In vivo bond strength remained stable in the CHX-treated specimens, while bond strength decreased significantly in control teeth. Resin-infiltrated dentin in CHX-treated specimens exhibited normal structural integrity of the collagen network. Conversely, progressive disintegration of the fibrillar network was identified in control specimens. Auto-degradation of collagen matrices can occur in resin-infiltrated dentin, but may be prevented by the application of a synthetic protease inhibitor, such as chlorhexidine.
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Chlorhexidine, Degradation, Etch-and-rinse adhesive, Hybrid layer, In vivo, MMP, bisphenol A bis(2 hydroxypropyl) ether dimethacrylate, chlorhexidine, dentin bonding agent, fibrillar collagen, matrix metalloproteinase, phosphoric acid, proteinase inhibitor, resin, single bond, unclassified drug, chemistry, dental acid etching, dental bonding, dental surgery, dentin, drug antagonism, human, materials testing, mechanical stress, methodology, surface property, tensile strength, time, transmission electron microscopy, ultrastructure, Acid Etching, Dental, Bisphenol A-Glycidyl Methacrylate, Composite Resins, Dental Bonding, Dental Restoration, Permanent, Dentin, Dentin-Bonding Agents, Fibrillar Collagens, Humans, Materials Testing, Matrix Metalloproteinases, Microscopy, Electron, Transmission, Phosphoric Acids, Protease Inhibitors, Stress, Mechanical, Surface Properties, Tensile Strength, Time Factors
Como citar
Journal of Dental Research, v. 86, n. 6, p. 529-533, 2007.