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dc.contributor.authorGuimaraes-Filho, Fabio
dc.contributor.authorTan, Doralice
dc.contributor.authorBraga, Joao
dc.contributor.authorRodrigues, Alexandre
dc.contributor.authorWaib, Paulo
dc.contributor.authorMatsubara, Beatriz [UNESP]
dc.date.accessioned2014-05-27T11:22:37Z
dc.date.available2014-05-27T11:22:37Z
dc.date.issued2007-10-15
dc.identifierhttp://dx.doi.org/10.1016/j.amjcard.2007.05.054
dc.identifier.citationAmerican Journal of Cardiology, v. 100, n. 8, p. 1303-1306, 2007.
dc.identifier.issn0002-9149
dc.identifier.urihttp://hdl.handle.net/11449/69938
dc.description.abstractDoppler echocardiography has been used for the diagnosis of anthracycline-induced cardiotoxicity. However, few data are available that include asymptomatic children previously treated with a low cumulative dose of this drug and therefore have a low risk of cardiac dysfunction. The aim of this study was to evaluate after-exercise cardiac function in asymptomatic children previously treated with a low cumulative dose of anthracycline and no clinical or laboratory evidence of cardiotoxicity. Doppler echocardiography was performed before and immediately after physical exercise in 29 children aged 5 to 17 years (anthracycline [ADRIA] group). All had finished cancer treatment with anthracycline derivatives for ≥1 year (cumulative dose 100 mg/m2). Results were compared with those from age- and gender-matched healthy children (control group; n = 26) using the Mann-Whitney rank test. Exercise-induced cardiac function changes within groups were analyzed using Wilcoxon's signed-rank test. Exercise induced significant increases in left ventricular systolic function indexes in both groups. However, the ADRIA group had significantly lower changes in left ventricular ejection fraction (ADRIA group 0.71 ± 0.02 vs 0.80 ± 0.04 and control group 0.71 ± 0.02 vs 0.89 ± 0.05, p = 0.0017) and end-systolic stress-volume index (ADRIA group 4.59 ± 0.69 vs 6.4 ± 2.0 g.cm-2/ml.m-2 and control group 5.49 ± 0.98 vs 11.54 ± 2.86 g.cm-2/ml.m-2; p <0.0001), indicating decreased functional systolic reserve. In conclusion, asymptomatic children previously treated with low cumulative doses of anthracycline had decreased functional systolic reserve evidenced by exercise, suggesting a nonclinically manifested cardiotoxicity. © 2007 Elsevier Inc. All rights reserved.en
dc.format.extent1303-1306
dc.language.isoeng
dc.relation.ispartofAmerican Journal of Cardiology
dc.sourceScopus
dc.subjectanthracycline
dc.subjectdaunorubicin
dc.subjectdoxorubicin
dc.subjectadolescent
dc.subjectchild
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectDoppler echocardiography
dc.subjectexercise
dc.subjectfemale
dc.subjectheart function
dc.subjectheart left ventricle ejection fraction
dc.subjectheart left ventricle performance
dc.subjecthuman
dc.subjectlow drug dose
dc.subjectmale
dc.subjectpriority journal
dc.subjectrank sum test
dc.subjecttreadmill exercise
dc.subjecttreatment duration
dc.subjectWilcoxon signed ranks test
dc.subjectAdolescent
dc.subjectAnthracyclines
dc.subjectAntibiotics, Antineoplastic
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCross-Sectional Studies
dc.subjectEchocardiography, Doppler
dc.subjectExercise Test
dc.subjectFemale
dc.subjectHeart Function Tests
dc.subjectHumans
dc.subjectMale
dc.subjectSystole
dc.subjectVentricular Dysfunction, Left
dc.titleVentricular Systolic Reserve in Asymptomatic Children Previously Treated With Low Doses of Anthracyclinesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionFaculdade de Medicina de Marília (FAMEMA)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationMarília Medical School, Sao Paulo
dc.description.affiliationBotucatu Medical School, Sao Paulo
dc.description.affiliationUnespBotucatu Medical School, Sao Paulo
dc.identifier.doi10.1016/j.amjcard.2007.05.054
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-34848826862
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.relation.ispartofjcr3.171
dc.relation.ispartofsjr1,930
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