Estudo histológico e imunoistoquímico do sistema nervoso central de cães naturalmente infectados por Leishmania (Leishmania) chagasi
Data
2007-12-01
Autores
Ikeda, Fabiana Augusta [UNESP]
Laurenti, Márcia Dalastra
Corbett, Carlos Eduardo
Feitosa, Mary Marcondes [UNESP]
Machado, Gisela Fabrino [UNESP]
Perri, Silvia Helena Venturoli [UNESP]
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Resumo
The present study aimed to characterize the histopathological alterations and to detect, by immunohistochemistry, the presence of amastigote forms of Leishmania in CNS tissue of dogs with and without neurological clinical signs of the disease. Two groups of animals were used: the first was composed of 18 dogs with visceral leishmaniasis without clinical evidence of neurological involvement, and the second, composed of 21 dogs with visceral leishmaniasis and neurological symptoms. The most frequent histopathological alterations found in the CNS of dogs of both groups were neuronal degeneration with neuronophagia, gliosis, leptomeningitis, vascular congestion, presence of perivascular lymphoplasmacytic infiltrate and areas of focal microhemorrhage. Antigen labeling for whole forms of Leishmania amastigotes was not observed in any fragment of the CNS of the dogs of either groups; however, most of them presented labeling of blood vessels walls, which suggests the presence of circulating parasite antigens.
Descrição
Palavras-chave
Central nervous system, Dogs, Histopathology, Immunohistochemistry, Leishmania chagasi, Animalia, Canis familiaris, Leishmania donovani chagasi
Como citar
Brazilian Journal of Veterinary Research and Animal Science, v. 44, n. 1, p. 5-11, 2007.