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dc.contributor.authorOliveira, Sandra Helena Penha de [UNESP]
dc.contributor.authorCanetti, C.
dc.contributor.authorRibeiro, R. A.
dc.contributor.authorCunha, F. Q.
dc.date.accessioned2014-05-27T11:22:48Z
dc.date.available2014-05-27T11:22:48Z
dc.date.issued2008-02-01
dc.identifierhttp://dx.doi.org/10.1007/s10753-007-9047-x
dc.identifier.citationInflammation, v. 31, n. 1, p. 36-46, 2008.
dc.identifier.issn0360-3997
dc.identifier.urihttp://hdl.handle.net/11449/70291
dc.description.abstractIn the present study, we investigate whether mast cells and macrophages are involved in the control of IL-1β-induced neutrophil migration, as well as the participation of chemotactic mediators. IL-1β induced a dose-dependent neutrophil migration to the peritoneal cavity of rats which depends on LTB 4, PAF and cytokines, since the animal treatment with inhibitors of these mediators (MK 886, PCA 4248 and dexamethasone respectively) inhibited IL-1β-induced neutrophil migration. The neutrophil migration induced by IL-1β is dependent on mast cells and macrophages, since depletion of mast cells reduced the process whereas the increase of macrophage population enhanced the migration. Moreover, mast cells or macrophages stimulated with IL-1β released a neutrophil chemotactic factor, which mimicked the neutrophil migration induced by IL-1β. The chemotactic activity of the supernatant of IL-1β-stimulated macrophages is due to the presence of LTB4, since MK 886 inhibited its release. Moreover, the chemotactic activity of IL-1β-stimulated mast cells supernatant is due to the presence of IL-1β and TNF-α, since antibodies against these cytokines inhibited its activity. Furthermore, significant amounts of these cytokines were detected in the supernatant. In conclusion, our results suggest that neutrophil migration induced by IL-1β depends upon LTB4 released by macrophages and upon IL-1β and TNFα released by mast cells. © 2007 Springer Science+Business Media, LLC.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.format.extent36-46
dc.language.isoeng
dc.relation.ispartofInflammation
dc.sourceScopus
dc.subjectIL-1β
dc.subjectLTB4
dc.subjectMast cells
dc.subjectNeutrophil migration
dc.subjectTNF-α
dc.subject1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid methyl 2 phenylthioethyl ester
dc.subject3 [3 tert butylthio 1 (4 chlorobenzyl) 5 isopropyl 2 indolyl] 2,2 dimethylpropionic acid
dc.subjectdexamethasone
dc.subjectinterleukin 1beta
dc.subjectleukotriene B4
dc.subjectthrombocyte activating factor
dc.subjecttumor necrosis factor alpha
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectcell stimulation
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectmacrophage
dc.subjectmale
dc.subjectmast cell
dc.subjectneutrophil
dc.subjectneutrophil chemotaxis
dc.subjectnonhuman
dc.subjectperitoneal cavity
dc.subjectprotein analysis
dc.subjectprotein function
dc.subjectprotein secretion
dc.subjectrat
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents
dc.subjectArachidonate 5-Lipoxygenase
dc.subjectCell Movement
dc.subjectInterleukin-1beta
dc.subjectLeukotriene B4
dc.subjectMacrophages
dc.subjectMacrophages, Peritoneal
dc.subjectMale
dc.subjectMast Cells
dc.subjectModels, Biological
dc.subjectNeutrophils
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTumor Necrosis Factor-alpha
dc.subjectAnimalia
dc.subjectRattus
dc.titleNeutrophil migration induced by IL-1β depends upon LTB4 released by macrophages and upon TNF-α and IL-1β released by mast cellsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFederal University of Rio de Janeiro
dc.contributor.institutionFederal University of Ceará
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationDepartment of Basic Science School of Dentistry Sao Paulo State University, Rua José Bonifácio, 1193, 16015-050 Araçatuba, Sao Paulo
dc.description.affiliationInstitute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro, Rio de Janeiro
dc.description.affiliationDepartment of Physiology and Pharmacology Faculty of Medicine Federal University of Ceará, Fortaleza, Ceará
dc.description.affiliationDepartment of Pharmacology Faculty of Medicine of Ribeirão Preto University of São Paulo, Ribeirão Preto, São Paulo
dc.description.affiliationUnespDepartment of Basic Science School of Dentistry Sao Paulo State University, Rua José Bonifácio, 1193, 16015-050 Araçatuba, Sao Paulo
dc.identifier.doi10.1007/s10753-007-9047-x
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-39049112964
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatubapt
dc.relation.ispartofjcr2.884
dc.relation.ispartofsjr1,023
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