Cinnamic acid is partially involved in propolis immunomodulatory action on human monocytes
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2013-06-12
Autores
Conti, Bruno José [UNESP]
Búfalo, Michelle Cristiane [UNESP]
Golim, Marjorie de Assis [UNESP]
Bankova, Vassya
Sforcin, José Maurício [UNESP]
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Resumo
Propolis is a beehive product used in traditional medicine due to its biological properties. It shows a complex chemical composition including phenolics, such as cinnamic acid (Ci). The mechanisms of action of propolis have been the subject of research recently; however, the involvement of Ci on propolis activity was not investigated on immune cells. Ci effects were evaluated on human monocytes, assessing the expression of Toll-like receptors (TLRs), HLA-DR, and CD80. Cytokine production (TNF-α and IL-10) and the fungicidal activity of monocytes were evaluated as well. Data showed that Ci downregulated TLR-2, HLA-DR, and CD80 and upregulated TLR-4 expression by human monocytes. High concentrations of Ci inhibited both TNF-α and IL-10 production, whereas the same concentrations induced a higher fungicidal activity against Candida albicans. TNF-α and IL-10 production was decreased by blocking TLR-4, while the fungicidal activity of monocytes was not affected by blocking TLRs. These results suggest that Ci modulated antigen receptors, cytokine production, and the fungicidal activity of human monocytes depending on concentration, and TLR-4 may be involved in its mechanism of action. Ci seemed to be partially involved in propolis activities. © 2013 Bruno José Conti et al.
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B7 antigen, cinnamic acid, HLA DR antigen, interleukin 10, propolis, toll like receptor 2, toll like receptor 4, tumor necrosis factor alpha, antiinflammatory activity, Candida albicans, cytokine production, down regulation, fungicidal activity, human, human cell, immunomodulation, monocyte, nonhuman, priority journal
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Evidence-based Complementary and Alternative Medicine, v. 2013.