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dc.contributor.authorBravo-Calderon, Diego Mauricio
dc.contributor.authorOliveira, Denise Tostes
dc.contributor.authorMarana, Aparecido Nilceu [UNESP]
dc.contributor.authorNonogaki, Suely
dc.contributor.authorCarvalho, Andre Lopes
dc.contributor.authorKowalski, Luiz Paulo
dc.identifier.citationCancer Biomarkers. Amsterdam: IOS Press, v. 10, n. 1, p. 51-59, 2011.
dc.description.abstractThe aim of this study was to evaluate the expression of beta 2-adrenergic receptor (beta 2-AR) in oral squamous cell carcinoma (OSCC) and to investigate the correlations between expression level and clinical characteristics, outcome, and patient prognosis. A total of 106 OSCC patients underwent surgical treatment at the A. C. Camargo Cancer Hospital, São Paulo, Brazil, were analyzed for clinicopathological data, treatment, tumor outcome, prognosis and immunohistochemical expression of beta 2-AR. The beta 2-AR expression was statistically analyzed relative to clinicopathological variables and survival using the Chi-square test, Kaplan-Meier curves and Cox regression model. Most OSCC (72.6%) exhibited malignant cells with strong cytoplasmatic and membranous beta 2-AR expression. beta 2-AR expression was significantly associated with alcohol (p = 0.021), simultaneous consumption of alcohol and tobacco (p = 0.014) and T stage (p = 0.07). In addition, OSCC patients who exhibited strong beta 2-AR expression demonstrated a higher rate of overall survival (p = 0.001) and cancer specific survival (p = 0.004) compared to patients with weak/negative beta 2-AR expression. The Cox regression model demonstrated that strong beta 2-AR expression was an independent favorable prognostic factor for OSCC patients. These results suggest that the strong malignant cell beta 2-AR expression is a favorable prognostic factor for OSCC patients and could be used as a target for new anti-neoplastic pharmacological strategies.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.publisherIOS Press
dc.relation.ispartofCancer Biomarkers
dc.sourceWeb of Science
dc.subjectOral canceren
dc.subjectadrenergic receptoren
dc.titlePrognostic significance of beta-2 adrenergic receptor in oral squamous cell carcinomaen
dcterms.rightsHolderIOS Press
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Adolfo Lutz (IAL)
dc.contributor.institutionCanc Hosp Barretos
dc.contributor.institutionCanc Hosp AC Camargo
dc.description.affiliationUniv São Paulo, Bauru Sch Dent, Area Pathol, Dept Stomatol, Bauru, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Sch Sci, Dept Comp, Bauru, Brazil
dc.description.affiliationAdolfo Lutz Inst, Div Pathol, São Paulo, Brazil
dc.description.affiliationCanc Hosp Barretos, Fundação Pio XII, Dept Head & Neck Surg, São Paulo, Brazil
dc.description.affiliationCanc Hosp AC Camargo, Dept Head & Neck Surg & Otorhinolaryngol, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sch Sci, Dept Comp, Bauru, Brazil
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdCNPq: 476139/2010-4
dc.description.sponsorshipIdCNPq: 500991/2010-3
dc.description.sponsorshipIdCNPq: 142790/2011-7
dc.description.sponsorshipIdFAPESP: 10/06333-3
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências, Baurupt
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