Indução da cardiomiopatia dilatada com Doxorrubicina em modelo experimental com coelhos
Carregando...
Arquivos
Data
2011-02-25
Autores
Gava, Fábio Nelson [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista (Unesp)
Resumo
A cardiomiopatia dilatada (CMD) é uma enfermidade caracterizada pelo aumento das câmaras cardíacas e disfunção sistólica. Devido ao fato dessa doença ainda apresentar prognóstico desfavorável aos seres humanos e animais, há a necessidade de criação de modelos experimentais da doença para o teste de novas terapias, como novos fármacos e células-tronco. No trabalho em tela, avaliou-se a indução da cardiomiopatia dilatada em coelhos com a administração de duas doses diferentes de doxorrubicina, por meio de achados radiográficos, eletrocardiográficos, ecodopplercardiográficos e histopatológicos. Foi observada redução significativa na função sistólica após seis semanas de indução, com diminuição da fração de encurtamento e de ejeção. Os achados histopatológicos demonstraram que a cardiotoxicidade decorrente do uso da doxorrubicina desenvolve-se tanto no ventrículo esquerdo quanto no septo interventricular e ventrículo direito. Os resultados desse estudo mostram que a espécie leporina pode ser utilizada como modelo experimental para indução da cardiomiopatia dilatada com doxorrubicina, na dose de 1mg/kg administrada duas vezes por semana por um período de seis semanas consecutivas
Dilated cardiomyopathy (DCM) is a disease characterized by increased cardiac chambers and systolic dysfunction. Because of the poor prognosis for humans and animals, studies with new therapeutic modalities have aroused great interest. Thus, there is a need for creation of experimental models of the disease for testing new therapies as new drugs and stem cells. This study was conceived to evaluate an experimental model of dilated cardiomyopathy induced in rabbits with administration of two different doses of chemotherapeutic agent doxorubicin, through radiography, electrocardiography, echodopplercardiography and histopathological findings. Significant reduction in systolic function after six weeks in treated animals, with decrease of ejection and shortening fraction were observed. The histopathologic findings demonstrated that cardiotoxicity due to administration of doxorrubicin occurs in left ventricle, as well as in interventricular septum and right ventricle. The results showed that rabbits can be used as an experimental model of induction of DCM with doxorrubicin, in the dose of 1mg/kg twice a week for a period of six consecutive weeks
Dilated cardiomyopathy (DCM) is a disease characterized by increased cardiac chambers and systolic dysfunction. Because of the poor prognosis for humans and animals, studies with new therapeutic modalities have aroused great interest. Thus, there is a need for creation of experimental models of the disease for testing new therapies as new drugs and stem cells. This study was conceived to evaluate an experimental model of dilated cardiomyopathy induced in rabbits with administration of two different doses of chemotherapeutic agent doxorubicin, through radiography, electrocardiography, echodopplercardiography and histopathological findings. Significant reduction in systolic function after six weeks in treated animals, with decrease of ejection and shortening fraction were observed. The histopathologic findings demonstrated that cardiotoxicity due to administration of doxorrubicin occurs in left ventricle, as well as in interventricular septum and right ventricle. The results showed that rabbits can be used as an experimental model of induction of DCM with doxorrubicin, in the dose of 1mg/kg twice a week for a period of six consecutive weeks
Descrição
Palavras-chave
Doxorrubicina, Histopatologia, Coelho, Ecodopplercardiografia, Doxorubicin, Histopathology, Rabbits, Echodopplercardiography
Como citar
GAVA, Fábio Nelson. Indução da cardiomiopatia dilatada com Doxorrubicina em modelo experimental com coelhos. 2011. xv, 53 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, 2011.