In vitro effect of low-fluoride toothpaste supplemented with sodium trimetaphosphate, xylitol, and erythritol on enamel demineralization

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dc.contributor.authorOliveira, Letícia Gonçalves [UNESP]
dc.contributor.authorDelbem, Alberto Carlos Botazzo [UNESP]
dc.contributor.authorGonçalves, Francyenne Maira Castro [UNESP]
dc.contributor.authorFernandes, Gabriela Leal Peres [UNESP]
dc.contributor.authorCannon, Mark L.
dc.contributor.authorDanelon, Marcelle [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionAnn and Robert Lurie Children's Hospital
dc.contributor.institutionFaculdade de Odontologia
dc.date.accessioned2023-07-29T16:10:23Z
dc.date.available2023-07-29T16:10:23Z
dc.date.issued2023-01-01
dc.description.abstractRegular use of toothpaste with fluoride (F) concentrations of ≥ 1000 ppm has been shown to contribute to reducing caries increment. However, when used by children during the period of dental development, it can lead to dental fluorosis. Objective: In this study, we aimed to evaluate the in vitro effect of a toothpaste formulation with reduced fluoride (F) concentration (200 ppm) supplemented with sodium trimetaphosphate (TMP: 0.2%), Xylitol (X:16%), and Erythritol (E: 4%) on dental enamel demineralization. Methodology: Bovine enamel blocks were selected according to initial surface hardness (SHi) and then divided into seven experimental toothpaste groups (n=12). These groups included 1) no F-TMP-X-E (Placebo); 2) 16% Xylitol and 4% Erythritol (X-E); 3) 16% Xylitol, 4% Erythritol and 0.2%TMP (X-E-TMP); 4) 200 ppm F (no X-E-TMP: (200F)); 5) 200 ppm F and 0.2% TMP (200F-TMP); 6) 200 ppm F, 16% Xylitol, 4% Erythritol, and 0.2% TMP (200F-X-E-TMP); and 7) 1,100 ppm F (1100F). Blocks were individually treated 2×/day with slurries of toothpastes and subjected to a pH cycling regimen for five days (DES: 6 hours and RE: 18 hours). Then, the percentage of surface hardness loss (%SH), integrated loss of subsurface hardness (ΔKHN), fluoride (F), calcium (Ca), and phosphorus (P) in enamel were determined. The data were analyzed by ANOVA (1-criterion) and the Student-Newman-Keuls test (p<0.001). Results: We found that the 200F-X-E-TMP treatment reduced %SH by 43% compared to the 1100F treatments (p<0.001). The ΔKHN was ~ 65% higher with 200F-X-E-TMP compared to 1100F (p<0.001). The highest concentration of F in enamel was observed on the 1100F treatment (p<0.001). The 200F-X-E-TMP treatment promote higher increase of Ca and P concentration in the enamel (p<0.001). Conclusion: The association of 200F-X-E-TMP led to a significant increase of the protective effect on enamel demineralization compared to the 1100F toothpaste.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia Departamento de Odontologia Restauradora e Preventiva, SP
dc.description.affiliationNorthwestern University Feinberg School of Medicine Ann and Robert Lurie Children's Hospital
dc.description.affiliationUniversidade de Ribeirão Preto (UNAERP) Faculdade de Odontologia, SP
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia Departamento de Odontologia Restauradora e Preventiva, SP
dc.identifierhttp://dx.doi.org/10.1590/1678-7757-2022-0410
dc.identifier.citationJournal of Applied Oral Science, v. 31.
dc.identifier.doi10.1590/1678-7757-2022-0410
dc.identifier.issn1678-7765
dc.identifier.issn1678-7757
dc.identifier.scopus2-s2.0-85151794428
dc.identifier.urihttp://hdl.handle.net/11449/249831
dc.language.isoeng
dc.relation.ispartofJournal of Applied Oral Science
dc.sourceScopus
dc.subjectDental enamel
dc.subjectErythritol
dc.subjectFluoride
dc.subjectPhosphate
dc.subjectTooth demineralization
dc.subjectXylitol
dc.titleIn vitro effect of low-fluoride toothpaste supplemented with sodium trimetaphosphate, xylitol, and erythritol on enamel demineralizationen
dc.typeArtigo

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Artigos - Odontologia Infantil e Social - FOA