Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy

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dc.contributor.authorFarah, Elaine [UNESP]
dc.contributor.authorCogni, Ana Lucia [UNESP]
dc.contributor.authorMinicucci, Marcos Ferreira [UNESP]
dc.contributor.authorGaiolla, Paula Schmidt Azevedo [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorZanati, Silmeia G. [UNESP]
dc.contributor.authorHaggeman, Rodrigo [UNESP]
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:33:22Z
dc.date.available2014-05-20T13:33:22Z
dc.date.issued2012-05-01
dc.description.abstractBackground: The consequences of aggressive therapy following a myocardial infarction (MI) on ventricular remodeling are not well established. Thus, the objective of this study was to analyze the prevalence, clinical characteristics, and predictors of left ventricular remodeling in the era of modern medical therapy.Material/Methods: Clinical characteristics and echocardiographic data were analyzed in 66 consecutive patients with anterior infarction at admission and at 6-month follow-up. Ventricular remodeling was defined as an increase of 10% in ventricular end-systolic or end-diastolic diameter.Results: In our study, 58% of patients presented with ventricular remodeling. Patients with remodeling possessed higher total plasma creatine kinase (CPK), MB-fraction (CPK-MB), heart rate, heart failure, shortness of breath, and reperfusion therapy than patients without remodeling. In contrast, patients with remodeling had a smaller ejection fraction, E-Wave deceleration time (EDT), and early (E' Wave) and late (A' Wave) diastolic mitral annulus velocity (average of septal and lateral walls), but a higher E/E' than patients without remodeling. Patients with remodeling used more diuretics, digoxin, oral anticoagulants and aldosterone antagonists than patients without remodeling. In the multivariate analyses, only E' Wave was an independent predictor of ventricular remodeling. Each 1 unit increase in the E' Wave was associated with a 59% increased odds of ventricular remodeling.Conclusions: In patients with anterior MI, despite contemporary treatment, ventricular remodeling is still a common event. In addition, diastolic function can have an important role as a predictor of remodeling in this scenario.en
dc.description.affiliationSão Paulo State Univ, Dept Internal Med, Botucatu Med Sch, UNESP, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Internal Med, Botucatu Med Sch, UNESP, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipBotucatu Medical School
dc.format.extentCR276-CR281
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22534706
dc.identifier.citationMedical Science Monitor. Smithtown: Int Scientific Literature, Inc, v. 18, n. 5, p. CR276-CR281, 2012.
dc.identifier.issn1234-1010
dc.identifier.lattes1590971576309420
dc.identifier.lattes6990977122340795
dc.identifier.lattes5016839015394547
dc.identifier.lattes1213140801402647
dc.identifier.lattes7438704034471673
dc.identifier.orcid0000-0002-5843-6232
dc.identifier.urihttp://hdl.handle.net/11449/11421
dc.identifier.wosWOS:000304535900010
dc.language.isoeng
dc.publisherInt Scientific Literature, Inc
dc.relation.ispartofMedical Science Monitor
dc.relation.ispartofsjr0,619
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectpredictorsen
dc.subjectremodelingen
dc.subjectventricular dilationen
dc.titlePrevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapyen
dc.typeArtigo
dcterms.rightsHolderInt Scientific Literature, Inc
unesp.author.lattes5016839015394547[10]
unesp.author.lattes6990977122340795
unesp.author.lattes1590971576309420
unesp.author.lattes1213140801402647[4]
unesp.author.lattes7438704034471673
unesp.author.orcid0000-0001-8980-8839[5]
unesp.author.orcid0000-0003-4412-1990[9]
unesp.author.orcid0000-0002-5980-4367[3]
unesp.author.orcid0000-0002-0607-8189[7]
unesp.author.orcid0000-0002-5843-6232[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Clínica Médica - FMB