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Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration

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dc.contributor.authorSaska, S. [UNESP]
dc.contributor.authorBarud, H. S. [UNESP]
dc.contributor.authorGaspar, A. M M [UNESP]
dc.contributor.authorMarchetto, Reinaldo [UNESP]
dc.contributor.authorRibeiro, Sidney José Lima [UNESP]
dc.contributor.authorMessaddeq, Younes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:26:11Z
dc.date.available2014-05-27T11:26:11Z
dc.date.issued2011-11-24
dc.description.abstractThe aim of this study was to develop and to evaluate the biological properties of bacterial cellulose-hydroxyapatite (BC-HA) nanocomposite membranes for bone regeneration. Nanocomposites were prepared from bacterial cellulose membranes sequentially incubated in solutions of CaCl2 followed by Na2HPO4. BC-HA membranes were evaluated in noncritical bone defects in rat tibiae at 1, 4, and 16 weeks. Thermogravimetric analyses showed that the amount of the mineral phase was 40-50 of the total weight. Spectroscopy, electronic microscopy/energy dispersive X-ray analyses, and X-ray diffraction showed formation of HA crystals on BC nanofibres. Low crystallinity HA crystals presented Ca/P a molar ratio of 1.5 (calcium-deficient HA), similar to physiological bone. Fourier transformed infrared spectroscopy analysis showed bands assigned to phosphate and carbonate ions. In vivo tests showed no inflammatory reaction after 1 week. After 4 weeks, defects were observed to be completely filled in by new bone tissue. The BC-HA membranes were effective for bone regeneration. © 2011 S. Saska et al.en
dc.description.affiliationInstitute of Chemistry University Estadual Paulista-UNESP, CP 355, 14-801-970 Araraquara, SP
dc.description.affiliationDepartment of Inorganic Chemistry Institute of ChemistryUNESP, Rua Francisco Degni s/n, 14-800-900 Araraquara, SP
dc.description.affiliationDepartment of Morphology Dental School University Estadual Paulista-UNESP, Rua Humaitá 1680, 14-801-903 Araraquara, SP
dc.description.affiliationUnespInstitute of Chemistry University Estadual Paulista-UNESP, CP 355, 14-801-970 Araraquara, SP
dc.description.affiliationUnespDepartment of Inorganic Chemistry Institute of ChemistryUNESP, Rua Francisco Degni s/n, 14-800-900 Araraquara, SP
dc.description.affiliationUnespDepartment of Morphology Dental School University Estadual Paulista-UNESP, Rua Humaitá 1680, 14-801-903 Araraquara, SP
dc.identifierhttp://dx.doi.org/10.1155/2011/175362
dc.identifier.citationInternational Journal of Biomaterials.
dc.identifier.doi10.1155/2011/175362
dc.identifier.file2-s2.0-81555220906.pdf
dc.identifier.issn1687-8787
dc.identifier.issn1687-8795
dc.identifier.lattes5711182251641103
dc.identifier.lattes6446047463034654
dc.identifier.lattes2998503841917815
dc.identifier.orcid0000-0003-3286-9440
dc.identifier.scopus2-s2.0-81555220906
dc.identifier.urihttp://hdl.handle.net/11449/72814
dc.language.isoeng
dc.relation.ispartofInternational Journal of Biomaterials
dc.relation.ispartofsjr0,511
dc.relation.ispartofsjr0,511
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleBacterial cellulose-hydroxyapatite nanocomposites for bone regenerationen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/aaa/guidelines/
dspace.entity.typePublication
unesp.author.lattes5711182251641103
unesp.author.lattes6446047463034654
unesp.author.lattes2998503841917815
unesp.author.lattes8379925533335630[3]
unesp.author.orcid0000-0003-3286-9440[5]
unesp.author.orcid0000-0002-7168-9971[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentMorfologia - FOARpt
unesp.departmentQuímica Inorgânica - IQARpt

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Araraquara - IQAR - Instituto de Química
Araraquara - FOAR - Faculdade de Odontologia