Impact of estradiol cypionate prior to TAI and progesterone supplementation at initial diestrus on ovarian and fertility responses in beef cows

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dc.contributor.authorMartins, T.
dc.contributor.authorTalamoni, J. P.
dc.contributor.authorSponchiado, M.
dc.contributor.authorMaio, J. R. G.
dc.contributor.authorNogueira, G. P. [UNESP]
dc.contributor.authorPugliesi, G.
dc.contributor.authorBinelli, M.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Camilo Castelo Branco
dc.contributor.institutionOuro Fino Saude Anim
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:42:03Z
dc.date.available2018-11-26T17:42:03Z
dc.date.issued2017-12-01
dc.description.abstractIn cattle, early diestrus progesterone (P4) supplementation modulates endometrial function to exert pro and anti-pregnancy establishment effects; specifically, P4 stimulates conceptus growth, but also induces early onset of luteolysis. This paradoxical effect is frequently related to the inconsistent fertility outcomes that result from P4 supplementation experiments. Aim was to investigate the impact of exogenous estradiol (E2) treatment at the end of timed fixed AI (TAI) on frequency of early luteolysis and pregnancy of beef cows supplemented with P4. Ovulations (DO of study) of suckled multiparous (n = 643) and primiparous (n = 193) Nelore cows (Bos indices) were synchronized with an E2/P4-based protocol for TAI and assigned to receive 1.0 mg of estradiol cypionate (CP) or nothing (NoCP) on D-2 and 150 mg of injectable long-acting P4 (iP4) or Placebo (NoiP4) on D4 on a 2 x 2 factorial arrangement. On D15, the iP4 supplementation increased (P < 0.05) the frequency of early luteolysis (NoCP + iP4: 26.0%; [13/50] vs. NoCP: 8.0% [4/50]), but CP prevented this effect (CP + iP4: 8.3% [4/48] and CP: 6.4% [3/471). The CP improved pregnancy/AI (P/AI) of multiparous (CP: 51.6% [165/320] and NoCP: 35.0% [113/323]; P < 0.001) and primiparous cows (CP: 40.4% [40/99] and NoCP: 24.5% [23/94], P < 0.05), regardless of iP4 treatment. The iP4 supplementation affected P/AI of CP and NoCP treated cows according to follicle size at TAI. For the CP treated cows, the iP4 supplementation improved P/AI of sub-populations of cows with follicles <12.35 mm (42.0% [34/81] vs. 53.1% [34/64]), while for NoCP treated cows, the improvements occurred in subpopulations of cows with follicles >= 12.35 mm (46.1% [35/76] vs. 58.7% [37/63]). In conclusion, strategies associating E2 and P4 supplementation decrease the incidence of early onset of luteolysis and improve P/AI of suckled beef cows with smaller follicles. (C) 2017 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Sao Paulo, Sch Vet Med & Anim Sci, Dept Anim Reprod, Pirassununga, SP, Brazil
dc.description.affiliationUniv Camilo Castelo Branco, Sch Vet Med, Dept Anim Reprod, Descalvado, SP, Brazil
dc.description.affiliationOuro Fino Saude Anim, Ribeirao Preto, SP, Brazil
dc.description.affiliationSao Paulo State Univ Julio de Mesquita Filho, Sch Vet Med Aracatuba, Dept Support Prod & Anim Hlth, Aracatuba, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ Julio de Mesquita Filho, Sch Vet Med Aracatuba, Dept Support Prod & Anim Hlth, Aracatuba, SP, Brazil
dc.description.sponsorshipLFEM
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdLFEM: 225
dc.description.sponsorshipIdFAPESP: 2011/03226-4
dc.description.sponsorshipIdFAPESP: 2015/26215-9
dc.description.sponsorshipIdCAPES: 33002010047P6
dc.format.extent156-163
dc.identifierhttp://dx.doi.org/10.1016/j.theriogenology.2017.08.017
dc.identifier.citationTheriogenology. New York: Elsevier Science Inc, v. 104, p. 156-163, 2017.
dc.identifier.doi10.1016/j.theriogenology.2017.08.017
dc.identifier.fileWOS000414384400022.pdf
dc.identifier.issn0093-691X
dc.identifier.urihttp://hdl.handle.net/11449/163445
dc.identifier.wosWOS:000414384400022
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTheriogenology
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBeef cattle
dc.subjectProestrus
dc.subjectLuteolysis
dc.subjectPregnancy
dc.subjectFollicle
dc.titleImpact of estradiol cypionate prior to TAI and progesterone supplementation at initial diestrus on ovarian and fertility responses in beef cowsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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