Bacterial cellulose/collagen hydrogel for wound healing
Nenhuma Miniatura disponível
De Sousa Moraes, Paula Rodrigues Fontes
Saska, Sybele [UNESP]
Barud, Hernane [UNESP]
De Lima, Lais Roncalho
Da Conceicao Amaro Martins, Virginia
De Guzzi Plepis, Ana Maria
Ribeiro, Sidney Jose Lima [UNESP]
Gaspar, Ana Maria Minarelli [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
This study compares a wound dressing based on bacterial cellulose/collagen (BC/COL) hydrogel in rat dorsum with commercial collagenase ointment and untreated wound. The hydrogel was characterized by Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), Fourier transformed-Infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). According to the In vivo test and macroscopic evaluation, BC/COL hydrogel showed a better repair of wounds and promoted statistically significant differences of tissue repair between treatments on the 7th day after surgery. Better quality, quantity and orientation evaluation of collagen fibers (p=0.0001) were observed in the BC/COL hydrogel and collagenase ointment groups in relation to the control group. The BC/COL hydrogel promoted better wound healing than collagenase and the control group, therefore, it can be considered a potential wound dressing for skin regeneration.
Bacterial cellulose, Collagen, Hydrogel, Tissue repair, Wound dressing
Materials Research, v. 19, n. 1, p. 106-116, 2016.