Bacterial cellulose/collagen hydrogel for wound healing

De Sousa Moraes, Paula Rodrigues Fontes; Saska, Sybele [UNESP]; Barud, Hernane [UNESP]; De Lima, Lais Roncalho; Da Conceicao Amaro Martins, Virginia; De Guzzi Plepis, Ana Maria; Ribeiro, Sidney Jose Lima [UNESP]; Gaspar, Ana Maria Minarelli [UNESP]

Bacterial cellulose/collagen hydrogel for wound healing

Arquivos

S1516-14392016000100106.pdf (4.4 MB)

Data

2016-01-01

Autores

De Sousa Moraes, Paula Rodrigues Fontes

Saska, Sybele

Barud, Hernane

De Lima, Lais Roncalho

Da Conceicao Amaro Martins, Virginia

De Guzzi Plepis, Ana Maria

Ribeiro, Sidney Jose Lima

Gaspar, Ana Maria Minarelli

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

This study compares a wound dressing based on bacterial cellulose/collagen (BC/COL) hydrogel in rat dorsum with commercial collagenase ointment and untreated wound. The hydrogel was characterized by Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), Fourier transformed-Infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). According to the In vivo test and macroscopic evaluation, BC/COL hydrogel showed a better repair of wounds and promoted statistically significant differences of tissue repair between treatments on the 7th day after surgery. Better quality, quantity and orientation evaluation of collagen fibers (p=0.0001) were observed in the BC/COL hydrogel and collagenase ointment groups in relation to the control group. The BC/COL hydrogel promoted better wound healing than collagenase and the control group, therefore, it can be considered a potential wound dressing for skin regeneration.