Stress hormones concentrations in the normal microenvironment predict risk for chemically induced cancer in rats

dc.contributor.authorValente, Vitor Bonetti [UNESP]
dc.contributor.authorVerza, Flávia Alves [UNESP]
dc.contributor.authorLopes, Felipe Yudi Kabeya [UNESP]
dc.contributor.authorFerreira, Joana Zafalon [UNESP]
dc.contributor.authordos Santos, Paulo Sérgio Patto [UNESP]
dc.contributor.authorSundefeld, Maria Lúcia Marçal Mazza [UNESP]
dc.contributor.authorBiasoli, Éder Ricardo [UNESP]
dc.contributor.authorMiyahara, Glauco Issamu [UNESP]
dc.contributor.authorSoubhia, Ana Maria Pires [UNESP]
dc.contributor.authorde Andrade, Mariza
dc.contributor.authorde Oliveira, Sandra Helena Penha [UNESP]
dc.contributor.authorBernabé, Daniel Galera [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionMayo Clinic College of Medicine
dc.date.accessioned2018-12-11T17:16:01Z
dc.date.available2018-12-11T17:16:01Z
dc.date.issued2018-03-01
dc.description.abstractEvidence show that stress hormones can influence cancer progression, but its role in carcinogenesis is poorly understood. In this study, we used a new method based on oral carcinogenesis model in rats to test the hypothesis that physiological levels of stress hormones in the normal tissue microenvironment would have significant predictive value for chemically induced cancer occurrence. Male Wistar rats were submitted to a tongue biopsy for measuring not-stress induced levels of norepinephrine, corticosterone, adrenocorticotropic hormone (ACTH) and brain-derived neurotrophic factor (BDNF) in the tissue before carcinogenic induction. Rats were treated with the 4-nitroquinoline-1-oxide (4NQO) chemical carcinogen for twenty weeks and then euthanized for microscopic evaluation of the tongue lesions. Increased pre-carcinogen norepinephrine concentrations and reduced basal corticosterone levels in the normal tissue microenvironment were predictive for oral squamous cell carcinoma (OSCC) occurrence. Likewise, increased pre-carcinogen norepinephrine levels in the normal microenvironment were associated a lower expression of pCDKN2a-p16 in OSCCs. Post-carcinogen levels of corticosterone and BDNF in oral leukoplakia tissues (precursor lesion of OSCC) and post-carcinogen corticosterone concentrations in OSCCs were higher than basal levels in the normal mucosa. Increased norepinephrine concentrations in OSCCs were associated to a greater tumor volume and thickness. Furthermore, higher levels of norepinephrine, ACTH and BDNF in OSCCs were associated to a lesser intensity of the lymphoplasmocytic infiltrate. This study shows that pre-carcinogen stress hormones levels in the normal microenvironment may be predictive for chemically induced cancer in rats. Moreover, chemical carcinogenesis can promote stressor-like effects with hormonal changes in the tissue microenvironment, which may be associated to tumor progression.en
dc.description.affiliationPsychoneuroimmunology Research Center Oral Oncology Center São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St.
dc.description.affiliationDepartment of Animal Clinic Surgery and Reproduction São Paulo State University (Unesp) School of Veterinary Medicine, 793 Clóvis Pestana St.
dc.description.affiliationDepartment of Statistics Oral Oncology Center São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St.
dc.description.affiliationDepartment of Pathology and Clinical Propedeutics São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St.
dc.description.affiliationDepartment of Biomedical Statistics and Informatics Mayo Clinic College of Medicine, 200 First St. SW
dc.description.affiliationImmunopharmacology Laboratory Department of Basic Sciences São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St.
dc.description.affiliationUnespPsychoneuroimmunology Research Center Oral Oncology Center São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St.
dc.description.affiliationUnespDepartment of Animal Clinic Surgery and Reproduction São Paulo State University (Unesp) School of Veterinary Medicine, 793 Clóvis Pestana St.
dc.description.affiliationUnespDepartment of Statistics Oral Oncology Center São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St.
dc.description.affiliationUnespDepartment of Pathology and Clinical Propedeutics São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St.
dc.description.affiliationUnespImmunopharmacology Laboratory Department of Basic Sciences São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St.
dc.format.extent229-238
dc.identifierhttp://dx.doi.org/10.1016/j.psyneuen.2017.11.001
dc.identifier.citationPsychoneuroendocrinology, v. 89, p. 229-238.
dc.identifier.doi10.1016/j.psyneuen.2017.11.001
dc.identifier.file2-s2.0-85033785940.pdf
dc.identifier.issn1873-3360
dc.identifier.issn0306-4530
dc.identifier.lattes3846891167083211
dc.identifier.lattes5331938962896664
dc.identifier.orcid0000-0002-5326-2026
dc.identifier.orcid0000-0002-8535-5569
dc.identifier.scopus2-s2.0-85033785940
dc.identifier.urihttp://hdl.handle.net/11449/175486
dc.language.isoeng
dc.relation.ispartofPsychoneuroendocrinology
dc.relation.ispartofsjr2,353
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBDNF
dc.subjectCancer
dc.subjectCarcinogenesis
dc.subjectOral cancer
dc.subjectStress hormones
dc.titleStress hormones concentrations in the normal microenvironment predict risk for chemically induced cancer in ratsen
dc.typeArtigo
unesp.author.lattes3846891167083211[7]
unesp.author.lattes5331938962896664[5]
unesp.author.orcid0000-0002-5326-2026[7]
unesp.author.orcid0000-0002-8535-5569[5]

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